caa a22 4500 475792807 CHVBK 20180406123715.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1011119107765 doi (NATIONALLICENCE)springer-10.1023/A:1011119107765 17β-Estradiol Protects Against Quinolinic Acid-Induced Lipid Peroxidation in the Rat Brain [Elektronische Daten] [Paula Heron, Santy Daya] The neurotoxin quinolinic acid has been identified as a causative agent in Huntington's disease and is a metabolite of the tryptophan pathway in the brain. In the present study, the in vivo and in vitro effect of 17β-estradiol on lipid peroxidation induced by quinolinic acid was investigated. For the in vivo experiments ovariectomized female rats were administered with 100 μg 17β-estradiol daily for seven days prior to and seven days following the intrahippocampal injection of 1 μmol quinolinic acid. The level of lipid peroxidation in brain homogenate was investigated using the thiobarbituric acid test. The in vitro experiments were performed in brain homogenates of ovariectomized female rats. The homogenate was treated with quinolinic acid alone or in combination with 17β-estradiol. Quinolinic acid increased lipid peroxidation in a dose dependent manner in vitro, while homogenate co-treated with 17β-estradiol showed a significant reduction in lipid peroxidation. 17β-estradiol was also shown to be protective against quinolinic acid in vivo. These results could explain the neuroprotective effect of 17β-estradiol. Plenum Publishing Corporation, 2000 Lipid peroxidation nationallicence quinolinic acid nationallicence 17β-estradiol nationallicence peroxy radical nationallicence Heron Paula Division of Pharmacology, Faculty of Pharmacy, Rhodes University, P.O. Box 94, 6140, Grahamstown, South Africa aut Daya Santy Division of Pharmacology, Faculty of Pharmacy, Rhodes University, P.O. Box 94, 6140, Grahamstown, South Africa aut Metabolic Brain Disease Kluwer Academic Publishers-Plenum Publishers 15/4(2000-12-01), 247-274 0885-7490 15:4<247 2000 15 11011 https://doi.org/10.1023/A:1011119107765 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1011119107765 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heron Paula Division of Pharmacology, Faculty of Pharmacy, Rhodes University, P.O. Box 94, 6140, Grahamstown, South Africa aut NATIONALLICENCE 700 1- Daya Santy Division of Pharmacology, Faculty of Pharmacy, Rhodes University, P.O. Box 94, 6140, Grahamstown, South Africa aut NATIONALLICENCE 773 0- Metabolic Brain Disease Kluwer Academic Publishers-Plenum Publishers 15/4(2000-12-01), 247-274 0885-7490 15:4<247 2000 15 11011 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer