caa a22 4500 475792823 CHVBK 20180406123715.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1011162922786 doi (NATIONALLICENCE)springer-10.1023/A:1011162922786 Glycosylation of Transferrin in Alzheimer's Disease and Alcohol-Induced Dementia [Elektronische Daten] [S.J. van Rensburg, P.A. Berman, F.C.V. Potocnik, J.J.F. Taljaard] Transferrin is a glycosylated metal-binding serum protein. Carbohydrate-deficient transferrin (CDT) is a marker of recent and heavy alcohol intake. A genetic variant of transferrin, TfC2, occurs with increased frequency in patients with Alzheimer's disease (AD). Hence the question arose whether, in addition to an altered amino acid sequence, there could also be a difference in the glycosylation state of transferrin in patients with dementia. Serum samples of 37 AD and 13 Alcohol-induced dementia patients as well as 10 healthy controls were analyzed for abnormal Tf variants, using isoelectric focusing followed by blotting with anti-Tf antibodies. This allowed the direct visualization of glycosylation variants of transferrin, and assessment of any increase in underglycosylated forms (di-, mono-and asialo transferrin). Plenum Publishing Corporation, 2000 Alzheimer's disease nationallicence carbohydrate deficient transferrin nationallicence CTD nationallicence van Rensburg S.J. Department of Chemical Pathology, Tygerberg Hospital and University of Stellenbosch Medical School, Tygerberg, South Africa aut Berman P.A. Department of Chemical Pathology, University of Cape Town, South Africa aut Potocnik F.C.V. Department of Psychiatry, University of Stellenbosch Medical School, Tygerberg, South Africa aut Taljaard J.J.F. Department of Chemical Pathology, Tygerberg Hospital and University of Stellenbosch Medical School, Tygerberg, South Africa aut Metabolic Brain Disease Kluwer Academic Publishers-Plenum Publishers 15/4(2000-12-01), 243-247 0885-7490 15:4<243 2000 15 11011 https://doi.org/10.1023/A:1011162922786 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1011162922786 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Rensburg S.J. Department of Chemical Pathology, Tygerberg Hospital and University of Stellenbosch Medical School, Tygerberg, South Africa aut NATIONALLICENCE 700 1- Berman P.A. Department of Chemical Pathology, University of Cape Town, South Africa aut NATIONALLICENCE 700 1- Potocnik F.C.V. Department of Psychiatry, University of Stellenbosch Medical School, Tygerberg, South Africa aut NATIONALLICENCE 700 1- Taljaard J.J.F. Department of Chemical Pathology, Tygerberg Hospital and University of Stellenbosch Medical School, Tygerberg, South Africa aut NATIONALLICENCE 773 0- Metabolic Brain Disease Kluwer Academic Publishers-Plenum Publishers 15/4(2000-12-01), 243-247 0885-7490 15:4<243 2000 15 11011 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer