caa a22 4500 475792882 CHVBK 20180406123715.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1011115006856 doi (NATIONALLICENCE)springer-10.1023/A:1011115006856 An Investigation into the Neuroprotective Properties of Ibuprofen [Elektronische Daten] [Zaynab Lambat, Natasha Conrad, Shailendra Anoopkumar-Dukie, Roderick Walker, Santy Daya] There is increasing evidence suggesting a protective role for anti-inflammatory medications in neurological disorders such as Alzheimer's disease (AD). While there has not been any direct evidence for this, a number of clinical studies indicate that those patients who have had a history of nonsteroidal anti-inflammatory use, have a lower incidence of AD. Since there is currently no evidence on the mechanism by which these agents offer possible neuroprotection, we investigated the potential neuroprotective properties of the nonsteroidal anti-inflammatory drug, ibuprofen, by examining whether this agent could reduce lipid peroxidation and superoxide radical generation. Quinolinic acid and cyanide, known neurotoxins, were used to induce lipid peroxidation and superoxide anion formation respectively, in rat brain homogenate. The results show that ibuprofen significantly (p<0.05) reduced quinolinic acid-induced lipid peroxidation and cyanide-induced superoxide production. The results of the present report therefore suggest a possible mechanism for the neuroprotective effect of ibuprofen. Plenum Publishing Corporation, 2000 Ibuprofen nationallicence neurodegeneration nationallicence free radical nationallicence Lambat Zaynab Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut Conrad Natasha Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut Anoopkumar-Dukie Shailendra Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut Walker Roderick Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut Daya Santy Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut Metabolic Brain Disease Kluwer Academic Publishers-Plenum Publishers 15/4(2000-12-01), 249-256 0885-7490 15:4<249 2000 15 11011 https://doi.org/10.1023/A:1011115006856 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1011115006856 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lambat Zaynab Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut NATIONALLICENCE 700 1- Conrad Natasha Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut NATIONALLICENCE 700 1- Anoopkumar-Dukie Shailendra Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut NATIONALLICENCE 700 1- Walker Roderick Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut NATIONALLICENCE 700 1- Daya Santy Faculty of Pharmacy, Rhodes University, 6140, Grahamstown, South Africa aut NATIONALLICENCE 773 0- Metabolic Brain Disease Kluwer Academic Publishers-Plenum Publishers 15/4(2000-12-01), 249-256 0885-7490 15:4<249 2000 15 11011 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer