caa a22 4500 47579947X CHVBK 20180406123733.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1002095608946 doi (NATIONALLICENCE)springer-10.1023/A:1002095608946 An Evaluation of Different Approaches for Behavior Genetic Analyses with Psychiatric Symptom Scores [Elektronische Daten] [Edwin van den Oord, Emily Simonoff, Lindon Eaves, Andrew Pickles, Judy Silberg, Hermine Maes] We used a simulation study to evaluate six approaches for behavior genetic analyses of psychiatric symptom scores. For the selection of the correct model, the best results were obtained with approaches using transformed scores in combination with a procedure involving p-values. With normalizing transformations, the χ2 test statistic gave a reasonable impression of the overall fit of the model but was less accurate when used as a difference test. The asymptotic distribution free estimation methods yielded χ2s that were much too large. All data analysis techniques yielded substantially biased parameter estimates. The most biased results were obtained with normalizing transformations. The least biased results were obtained with tobit correlations, but because of its large standard errors the most precise estimates were obtained with polychoric correlations and optimal scale scores. An empirical study showed that a recognition of the role of methodological factors was helpful to understand part of the differences between assessment instruments, raters, and data analysis techniques that were found in the real data. Plenum Publishing Corporation, 2000 Behavior genetics nationallicence twins nationallicence psychopathology nationallicence censoring nationallicence multiple raters: symptom scores nationallicence simulation study nationallicence van den Oord Edwin MRC Child Psychiatry Unit, Institute of Psychiatry, London, U.K. aut Simonoff Emily MRC Child Psychiatry Unit, Institute of Psychiatry, London, U.K. aut Eaves Lindon Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia aut Pickles Andrew MRC Child Psychiatry Unit, Institute of Psychiatry, London, U.K. aut Silberg Judy Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia aut Maes Hermine Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/1(2000-01-01), 1-18 0001-8244 30:1<1 2000 30 10519 https://doi.org/10.1023/A:1002095608946 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1002095608946 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van den Oord Edwin MRC Child Psychiatry Unit, Institute of Psychiatry, London, U.K aut NATIONALLICENCE 700 1- Simonoff Emily MRC Child Psychiatry Unit, Institute of Psychiatry, London, U.K aut NATIONALLICENCE 700 1- Eaves Lindon Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia aut NATIONALLICENCE 700 1- Pickles Andrew MRC Child Psychiatry Unit, Institute of Psychiatry, London, U.K aut NATIONALLICENCE 700 1- Silberg Judy Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia aut NATIONALLICENCE 700 1- Maes Hermine Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/1(2000-01-01), 1-18 0001-8244 30:1<1 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer