caa a22 4500 475799569 CHVBK 20180406123733.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1010232900342 doi (NATIONALLICENCE)springer-10.1023/A:1010232900342 Epistatic Quantitative Trait Loci for Alcohol Preference in Mice [Elektronische Daten] [José Fernández, Lisa Tarantino, Scott Hofer, George Vogler, Gerald McClearn] Alcohol consumption is a complex trait, responding to the influence of various genes and environmental influences acting in a quantitative fashion. Various studies in alcohol consumption processes have identified quantitative trait locus (QTL) regions across the mouse genome that appear to contribute to this phenotype. The purpose of this study was to examine the influence of interactions between alleles at different loci, a phenomenon known as epistasis, on previously identified QTLs for alcohol consumption in mice. A multiple regression model was developed and applied to test for the significance of the interaction between two QTLs and to quantify this interaction. Our results indicate the presence of epistasis between loci on mouse chromosomes 2 and 3 accounting for 7-8% of the variation in alcohol preference, respectively. Plenum Publishing Corporation, 2000 Epistasis nationallicence QTL nationallicence alcohol consumption nationallicence gene interaction nationallicence mice nationallicence Fernández José Obesity Research Center, St. Luke's-Roosevelt Hospital Center, 10025, New York, New York aut Tarantino Lisa Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut Hofer Scott Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut Vogler George Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut McClearn Gerald Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/6(2000-11-01), 431-437 0001-8244 30:6<431 2000 30 10519 https://doi.org/10.1023/A:1010232900342 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1010232900342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández José Obesity Research Center, St. Luke's-Roosevelt Hospital Center, 10025, New York, New York aut NATIONALLICENCE 700 1- Tarantino Lisa Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut NATIONALLICENCE 700 1- Hofer Scott Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut NATIONALLICENCE 700 1- Vogler George Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut NATIONALLICENCE 700 1- McClearn Gerald Center for Developmental and Health Genetics, The Pennsylvania State University, 16802, University Park, Pennsylvania aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/6(2000-11-01), 431-437 0001-8244 30:6<431 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer