caa a22 4500 475799615 CHVBK 20180406123733.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1010246717180 doi (NATIONALLICENCE)springer-10.1023/A:1010246717180 Behavioral Profiles of Genetically Selected Aggressive and Nonaggressive Male Wild House Mice in Two Anxiety Tests [Elektronische Daten] [Sandy Hogg, Maleen Hof, Hanno Würbel, Thierry Steimer, Anne de Ruiter, Jaap Koolhaas, Frans Sluyter] Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light-dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for different levels of trait anxiety. The tunnel maze consists of an open, brightly lit central arena surrounded by a complex system of interconnecting tunnels. As in the LD box, animals which spend less time and are less active in the brightly illuminated section of the maze are considered to have higher anxiety levels. In the tunnel maze, the LAL mice showed more exploration and spent more time in the central arena than the SAL animals, but only during the final 2 min of the 6-min test. This reduced preference for the central arena was not due to general inactivity or a failure of the SAL to find the central arena and indicates a higher level of state anxiety in the aggressive animals. In contrast, no "anxiety-like” differences were found in the LD box, either for the percentage of time spent in the light compartment or for the number of crossings. SAL males actually showed higher levels of moving and rearing, and lower levels of freezing, than did LAL males. Plenum Publishing Corporation, 2000 Tunnel maze nationallicence light-dark box nationallicence aggression nationallicence anxiety nationallicence coping strategy nationallicence selection lines nationallicence habituation nationallicence Hogg Sandy Department of Psychopharmacology Depression, H. Lundbeck A/S, Ottiliavej 9, 2500, Copenhagen-Valby, Denmark aut Hof Maleen Department of Psychoneuropharmacology, University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Würbel Hanno Institute of Animal Sciences, Physiology and Husbandry, ETH Zürich, Schorenstrasse 16/SLA B14, 8603, Schwerzenbach, Switzerland aut Steimer Thierry Clinical Psychopharmacology Unit, UPG Department of Psychiatry, University of Geneva, 100 Avenue de Bel-Air, CH-1225, Chene-Bourg, Switzerland aut de Ruiter Anne Department of Animal Physiology, University of Groningen, P.O. Box 14, 9750 AA, Haren, The Netherlands aut Koolhaas Jaap Department of Animal Physiology, University of Groningen, P.O. Box 14, 9750 AA, Haren, The Netherlands aut Sluyter Frans Department of Biological Psychology, Vrije Universiteit, De Boelelaan 1111, 1081 HV, Amsterdam, The Netherlands aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/6(2000-11-01), 439-446 0001-8244 30:6<439 2000 30 10519 https://doi.org/10.1023/A:1010246717180 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1010246717180 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hogg Sandy Department of Psychopharmacology Depression, H. Lundbeck A/S, Ottiliavej 9, 2500, Copenhagen-Valby, Denmark aut NATIONALLICENCE 700 1- Hof Maleen Department of Psychoneuropharmacology, University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Würbel Hanno Institute of Animal Sciences, Physiology and Husbandry, ETH Zürich, Schorenstrasse 16/SLA B14, 8603, Schwerzenbach, Switzerland aut NATIONALLICENCE 700 1- Steimer Thierry Clinical Psychopharmacology Unit, UPG Department of Psychiatry, University of Geneva, 100 Avenue de Bel-Air, CH-1225, Chene-Bourg, Switzerland aut NATIONALLICENCE 700 1- de Ruiter Anne Department of Animal Physiology, University of Groningen, P.O. Box 14, 9750 AA, Haren, The Netherlands aut NATIONALLICENCE 700 1- Koolhaas Jaap Department of Animal Physiology, University of Groningen, P.O. Box 14, 9750 AA, Haren, The Netherlands aut NATIONALLICENCE 700 1- Sluyter Frans Department of Biological Psychology, Vrije Universiteit, De Boelelaan 1111, 1081 HV, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/6(2000-11-01), 439-446 0001-8244 30:6<439 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer