caa a22 4500 475799631 CHVBK 20180406123733.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1001970425822 doi (NATIONALLICENCE)springer-10.1023/A:1001970425822 Some Properties of a Variance Components Model for Fine-Mapping Quantitative Trait Loci [Elektronische Daten] [Lon Cardon, Gonçalo Abecasis] Identifying etiological variants for multifactorial traits by allelic association holds promise when many markers are available in close proximity. However, evidence for or against association at any particular marker does not provide any direct information about the influence of causal variants or the frequency of the etiologic allele(s). Recently, a variance components model of linkage and association was developed for quantitative traits which is sufficiently flexible to provide some insights into these issues. We show that this combined linkage/association model provides an estimate of the additive genetic variance of a trait that is attributable to disequilibrium between the marker and QTL. We use this estimate to construct approximate boundaries of the minimum level of disequilibrium between an observed marker and unobserved QTL and to delimit the permissible range of allele frequencies at the QTL based on available data at nearby markers. This information may facilitate fine-mapping studies of complex traits that aim to localize QTLs by assessment of association with many markers in a candidate region of interest. Plenum Publishing Corporation, 2000 Quantitative trait loci nationallicence single nucleotide polymorphisms nationallicence linkage nationallicence associations nationallicence variance components nationallicence Cardon Lon The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, U.K. aut Abecasis Gonçalo The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, U.K. aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/3(2000-05-01), 235-243 0001-8244 30:3<235 2000 30 10519 https://doi.org/10.1023/A:1001970425822 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1001970425822 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cardon Lon The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, U.K aut NATIONALLICENCE 700 1- Abecasis Gonçalo The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, U.K aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/3(2000-05-01), 235-243 0001-8244 30:3<235 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer