caa a22 4500 475799712 CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1001962124005 doi (NATIONALLICENCE)springer-10.1023/A:1001962124005 Breaking Through Artificial Selection Limits of an Adaptive Behavior in Mice and the Consequences for Correlated Responses [Elektronische Daten] [Abel Bult, Carol Lynch] Previous divergent selection for nest-building behavior at 22 ± 1°C resulted in a 40-fold difference between the high and the low lines in amount of cotton used to build a nest. Correlated responses to selection indicated positive genetic correlations with body weight, nest-building at 4 ± 1°C, and litter size and negative genetic correlations with food consumption. At generation 46, the replicate high-selected (High 1 × High 2), randomly bred control (Control 1 × Control 2), and low-selected (Low 1 × Low 2) lines were crossed and the F1 showed significant heterosis for nest-building behavior. Regression of the F3 on the F2 generation gave heritability estimates of 0.16 ± 0.10 for the high and 0.07 ± 0.10 for the low cross, revealing a potential to break the selection limit (at least in the high direction), which had been reached at about 20 generations of selection. Indeed, renewed selection resulted in responses in both the high and the low directions of nesting, yielding realized heritabilities of 0.29 ± 0.02 and 0.30 ± 0.004, respectively. Replicated renewed selection, using the F3 generation as the base population, in the high direction of nesting resulted in correlated increases in nest-building at 4 ± 1°C, litter size, and food consumption. Body weight did not change. The positive correlation with food consumption is opposite in sign compared to the original selection experiment. This indicates that the evolutionary potential of a population to adapt to a changing environment not only depends on its current genetic variability in one adaptive trait, but may be constrained by genetic correlations changing over the course of selection. Plenum Publishing Corporation, 2000 Artificial selection nationallicence correlated responses nationallicence nest-building behavior nationallicence Mus domesticus nationallicence realized heritability nationallicence evolution nationallicence Bult Abel Biology Department, Wesleyan University, 06459-0170, and, Middletown, Connecticut aut Lynch Carol Department of Environmental, Population and Organismic Biology, University of Colorado, 80309-0334, Boulder, Colorado aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/3(2000-05-01), 193-206 0001-8244 30:3<193 2000 30 10519 https://doi.org/10.1023/A:1001962124005 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1001962124005 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bult Abel Biology Department, Wesleyan University, 06459-0170, and, Middletown, Connecticut aut NATIONALLICENCE 700 1- Lynch Carol Department of Environmental, Population and Organismic Biology, University of Colorado, 80309-0334, Boulder, Colorado aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/3(2000-05-01), 193-206 0001-8244 30:3<193 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer