caa a22 4500 475799801 CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1026505702343 doi (NATIONALLICENCE)springer-10.1023/A:1026505702343 van den Oord Edwin Department of Child and Adolescent Psychology, Utrecht University, Utrecht, The Netherlands aut The Use of Mixture Models to Perform Quantitative Tests for Linkage Disequilibrium, Maternal Effects, and Parent-of-Origin Effects with Incomplete Subject—Parent Triads [Elektronische Daten] [Edwin van den Oord] The transmission disequilibrium test and related methods require complete triads of genotyped cases plus both parents to test for linkage disequilibrium in the presence of population stratification. Based on the work of Weinberg (1999ab) and Schaid and Li (1997) with dichotomous outcomes, we discuss how additional tests for maternal or parent-of-origin effects can be performed and incomplete subject—parent triads can be used in situations where the outcome is a quantitative variable. This is achieved using a finite mixture model where class membership is known for complete triads and unknown for incomplete triads. Simulations were performed assuming different genetic models and various amounts of missing parental genotypes. Results showed that the tests resulted in accurate Type I errors, recovered much of the loss in information caused by missing genotypes, and yielded unbiased parameter estimates. Extensions of the model to nuclear families, multiple loci, and multiple outcome variables are briefly discussed. Plenum Publishing Corporation, 2000 QTL nationallicence mixture model nationallicence association study nationallicence transmission disequilibrium tests nationallicence maternal effect nationallicence imprinting nationallicence Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 335-343 0001-8244 30:4<335 2000 30 10519 https://doi.org/10.1023/A:1026505702343 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026505702343 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- van den Oord Edwin Department of Child and Adolescent Psychology, Utrecht University, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 335-343 0001-8244 30:4<335 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer