caa a22 4500 47579981X CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1026593232385 doi (NATIONALLICENCE)springer-10.1023/A:1026593232385 Two Mouse Lines Selected for Differential Sensitivities to β-Carboline-Induced Seizures Are Also differentially Sensitive to Various Pharmacological Effects of Other GABAA Receptor Ligands [Elektronische Daten] [Daisy Rinaldi, Benjamin Boutre, Joelle Adrien, Patrice Venault, Georges Chapouthier] Two mouse lines were selectively bred according to their sensitivity (BS line) or resistance (BR line) to seizures induced by a single i.p. injection of methyl β-carboline-3-carboxylate (β-CCM), an inverse agonist of the GABAA receptor benzodiazepine site. Our aim was to characterize both lines' sensitivities to various physiological effects of other ligands of the GABAA receptor. We measured diazepam-induced anxiolysis with the elevated plus-maze test, diazepam-induced sedation by recording the vigilance states, and picrotoxin- and pentylenetetrazol-induced seizures after i.p. injections. Results presented here show that the differential sensitivities of BS and BR lines to β-CCM can be extended to diazepam, picrotoxin, and pentylenetetrazol, suggesting a genetic selection of a general sensitivity and resistance to several ligands of the GABAA receptor. Plenum Publishing Corporation, 2000 Selectively bred mice nationallicence β-carboline nationallicence seizures nationallicence benzodiazepine nationallicence behavior nationallicence GABAA receptors nationallicence Rinaldi Daisy Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, 91 Bd de l'Hôpital, 75634, Paris Cedex 13, France aut Boutre Benjamin Groupe Hospitalier Pitié-Salpêtrière, INSERM U288, 91 Bd de l'Hôpital, 75634, París Cedex 13, France aut Adrien Joelle Groupe Hospitalier Pitié-Salpêtrière, INSERM U288, 91 Bd de l'Hôpital, 75634, París Cedex 13, France aut Venault Patrice Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, 91 Bd de l'Hôpital, 75634, Paris Cedex 13, France aut Chapouthier Georges Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, 91 Bd de l'Hôpital, 75634, Paris Cedex 13, France aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 277-284 0001-8244 30:4<277 2000 30 10519 https://doi.org/10.1023/A:1026593232385 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026593232385 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rinaldi Daisy Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, 91 Bd de l'Hôpital, 75634, Paris Cedex 13, France aut NATIONALLICENCE 700 1- Boutre Benjamin Groupe Hospitalier Pitié-Salpêtrière, INSERM U288, 91 Bd de l'Hôpital, 75634, París Cedex 13, France aut NATIONALLICENCE 700 1- Adrien Joelle Groupe Hospitalier Pitié-Salpêtrière, INSERM U288, 91 Bd de l'Hôpital, 75634, París Cedex 13, France aut NATIONALLICENCE 700 1- Venault Patrice Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, 91 Bd de l'Hôpital, 75634, Paris Cedex 13, France aut NATIONALLICENCE 700 1- Chapouthier Georges Groupe Hospitalier Pitié-Salpêtrière, CNRS UMR 7593, 91 Bd de l'Hôpital, 75634, Paris Cedex 13, France aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 277-284 0001-8244 30:4<277 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer