caa a22 4500 475799828 CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1026545316455 doi (NATIONALLICENCE)springer-10.1023/A:1026545316455 Habituation of Activity in an Open Field: A Survey of Inbred Strains and F1 Hybrids [Elektronische Daten] [Valerie Bolivar, Barbara Caldarone, Andrew Reilly, Lorraine Flaherty] To determine if there is genetic variability in habituation of activity in an open field, we examined a number of inbred strains and F1 hybrids. Using 5-min exposures to a dark open field, we measured changes in exploratory behavior over 3 consecutive days in 129S3/SvImJ, A/J, BALB/ cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J, FVB/NJ, (B6 × 129)F1/J, and (B6 × C3H) F1/J male and female mice. Strain differences in open-field activity and in habituation were evident. Some of the strain differences were further modified by sex. The strains and F1's could be separated into groups that increased, decreased, or did not modify their activities across testing sessions. In a second study, the effects of altering the floor surface on habituation were examined in male 129S3/SvImJ, C57BL/6J, DBA/2J, and (B6 × 129)F1/J mice. When the floor was altered after 3 consecutive days of habituation, increased activity levels were evident. There were strain differences in the responsiveness to the changes in the floor. These results confirm a genetic role in intersession habituation to an open field. Plenum Publishing Corporation, 2000 Inbred strains nationallicence habituation nationallicence open-field activity nationallicence Bolivar Valerie Genomics Institute, Wadsworth Center, 12201-2002, Albany, New York aut Caldarone Barbara Genomics Institute, Wadsworth Center, 12201-2002, Albany, New York aut Reilly Andrew Laboratory of Structural Pathology, Wadsworth Center, 12201-2002, Albany, New York aut Flaherty Lorraine Genomics Institute, Wadsworth Center, 12201-2002, Albany, New York aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 285-293 0001-8244 30:4<285 2000 30 10519 https://doi.org/10.1023/A:1026545316455 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026545316455 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bolivar Valerie Genomics Institute, Wadsworth Center, 12201-2002, Albany, New York aut NATIONALLICENCE 700 1- Caldarone Barbara Genomics Institute, Wadsworth Center, 12201-2002, Albany, New York aut NATIONALLICENCE 700 1- Reilly Andrew Laboratory of Structural Pathology, Wadsworth Center, 12201-2002, Albany, New York aut NATIONALLICENCE 700 1- Flaherty Lorraine Genomics Institute, Wadsworth Center, 12201-2002, Albany, New York aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 285-293 0001-8244 30:4<285 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer