caa a22 4500 475799844 CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1023/A:1026549417364 doi (NATIONALLICENCE)springer-10.1023/A:1026549417364 Self-Reported Zygosity and the Equal-Environments Assumption for Psychiatric Disorders in the Vietnam Era Twin Registry [Elektronische Daten] [Hong Xian, Jeffrey Scherrer, Seth Eisen, William True, Andrew Heath, Jack Goldberg, Michael Lyons, Ming Tsuang] The equal-environments assumption (EEA) in twin studies of psychiatric disorders assumes that the family environment which contributes to risk for a disorder is equally correlated between monozygotic (MZ) and dizygotic (DZ) twin pairs. In a study of psychiatric disorders in female twins, Kendler and colleagues (1993) have demonstrated the utility of a test of the EEA which includes a specified family environmental factor defined by using measures of perceived zygosity. We tested the EEA assumption among 3155 male—male twin pair members of the Vietnam Era Twin Registry for the following DSM-III-R lifetime disorders: alcohol dependence, marijuana dependence, any illicit drug dependence, nicotine dependence, major depression, and posttraumatic stress disorder. The majority of MZ (81.6%; n = 1593) and DZ (90.2%; n = 1086) twin pairs agreed with the investigator's assigned zygosity. The best-fitting model for each of these disorders did not allow for a specified family environmental influence. These results support the usefulness of perceived zygosity in tests of the EEA. In male twin pairs, perceived zygosity has little impact on twin similarity for common psychiatric disorders. Plenum Publishing Corporation, 2000 Equal-environments assumption nationallicence twins nationallicence psychiatric disorders nationallicence veterans nationallicence males nationallicence Xian Hong Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut Scherrer Jeffrey Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut Eisen Seth Research and Medical Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut True William Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut Heath Andrew Missouri Alcoholism Research Center. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri aut Goldberg Jack Health Services Research and Development Service and Cooperative Studies Program Coordinating Center, Department of Veterans Affairs, Hines, Illinois aut Lyons Michael Department of Psychology, Boston University, Boston, Massachusetts aut Tsuang Ming Department of Psychiatry at the Brockton/West Roxbury VA, Harvard Medical School, Brockton, Massachusetts aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 303-310 0001-8244 30:4<303 2000 30 10519 https://doi.org/10.1023/A:1026549417364 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026549417364 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xian Hong Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut NATIONALLICENCE 700 1- Scherrer Jeffrey Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut NATIONALLICENCE 700 1- Eisen Seth Research and Medical Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut NATIONALLICENCE 700 1- True William Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri aut NATIONALLICENCE 700 1- Heath Andrew Missouri Alcoholism Research Center. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri aut NATIONALLICENCE 700 1- Goldberg Jack Health Services Research and Development Service and Cooperative Studies Program Coordinating Center, Department of Veterans Affairs, Hines, Illinois aut NATIONALLICENCE 700 1- Lyons Michael Department of Psychology, Boston University, Boston, Massachusetts aut NATIONALLICENCE 700 1- Tsuang Ming Department of Psychiatry at the Brockton/West Roxbury VA, Harvard Medical School, Brockton, Massachusetts aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/4(2000-07-01), 303-310 0001-8244 30:4<303 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer