caa a22 4500 475799941 CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1001903221046 doi (NATIONALLICENCE)springer-10.1023/A:1001903221046 Differential Susceptibility to Periodontitis in Genetically Selected Wistar Rat Lines that Differ in their Behavioral and Endocrinological Response to Stressors [Elektronische Daten] [Torbjørn Breivik, Frans Sluyter, Maleen Hof, Alexander Cools] This study tests the model presented previously by Breivik et al. (1996), in which the extent of periodontitis, an inflammatory disease, is predicted from the reactivity of the HPA-axis. Briefly, the model implies that elevated plasma levels of corticosterone modulate the immune system by shifting the T-helper balance toward a more Th2 response, which, alternately, increases the sensitivity to periodontitis. To test this model, two genetically distinct types of rats that differ both behaviorally and endocrinologically in their response to stress (high corticosterone responding APO-SUS rats and low corticosterone responding APO-UNSUS rats) were compared. Periodontitis was experimentally induced through the placement of a ligature and measured as the extent of tissue (fiber and bone) loss, both histologically and radiographically. The results show that, as expected, APO-SUS animals are more sensitive to periodontitis, i.e., show more fiber and bone loss, than APO-UNSUS animals. These data are in agreement with findings in Fischer and Lewis rats, as well as with corticosterone treated and adrenalectomized animals and suggest that genetic factors underlying the variation in the reactivity of the HPA-axis (and, accordingly, their behavioral response to stress) play an important a role in the development of inflammatory diseases. Plenum Publishing Corporation, 2000 Periodontitis nationallicence stress nationallicence corticosterone nationallicence selected rat lines (APO-UNSUS/SUS) nationallicence bone loss nationallicence Breivik Torbjørn Department of Periodontology, Faculty of Dentistry, University of Oslo, Norway aut Sluyter Frans Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands aut Hof Maleen Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands aut Cools Alexander Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/2(2000-03-01), 123-130 0001-8244 30:2<123 2000 30 10519 https://doi.org/10.1023/A:1001903221046 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1001903221046 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Breivik Torbjørn Department of Periodontology, Faculty of Dentistry, University of Oslo, Norway aut NATIONALLICENCE 700 1- Sluyter Frans Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Hof Maleen Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Cools Alexander Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/2(2000-03-01), 123-130 0001-8244 30:2<123 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer