caa a22 4500 47579995X CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1001907321955 doi (NATIONALLICENCE)springer-10.1023/A:1001907321955 Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits [Elektronische Daten] [Sofie Van Gestel, Jeanine Houwing-Duistermaat, Rolf Adolfsson, Cornelia van Duijn, Christine Van Broeckhoven] A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus ϖ = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait. Plenum Publishing Corporation, 2000 Selective genotyping nationallicence power nationallicence QTL nationallicence association analysis nationallicence Van Gestel Sofie Department of Biochemistry, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Belgium aut Houwing-Duistermaat Jeanine Institute of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands aut Adolfsson Rolf Institute of Psychiatry, University of Umeå, Sweden aut van Duijn Cornelia Institute of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands aut Van Broeckhoven Christine Department of Biochemistry, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Belgium aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/2(2000-03-01), 141-146 0001-8244 30:2<141 2000 30 10519 https://doi.org/10.1023/A:1001907321955 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1001907321955 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Gestel Sofie Department of Biochemistry, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Belgium aut NATIONALLICENCE 700 1- Houwing-Duistermaat Jeanine Institute of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Adolfsson Rolf Institute of Psychiatry, University of Umeå, Sweden aut NATIONALLICENCE 700 1- van Duijn Cornelia Institute of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Van Broeckhoven Christine Department of Biochemistry, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Belgium aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/2(2000-03-01), 141-146 0001-8244 30:2<141 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer