caa a22 4500 475799992 CHVBK 20180406123734.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1001951104208 doi (NATIONALLICENCE)springer-10.1023/A:1001951104208 Mice Lacking PKCγ Exhibit Decreased Anxiety [Elektronische Daten] [Barbara Bowers, Allan Collins, Theresa Tritto, Jeanne Wehner] To investigate the contribution of the PKCγ isoform of protein kinase C (PKC) in neurochemical pathways regulating anxiety, mice lacking the gene encoding PKCγ were tested with heterozygote and wild-type littermates in three approach-avoidance tests of anxiety. Null mutant mice consistently displayed a decrease in baseline anxiety-related behaviors in the elevated plus-maze, the black/white box, and the mirrored chamber. In the elevated plus-maze, mutant mice entered the open arms significantly more often and spent more time in the open arms of the maze. In the black/white box, transitions between the compartments were greatest in the null mutant mice, and in the mirrored chamber, mutant mice were markedly less anxious with significantly decreased latencies to enter and more time spent in the chamber. Indices of locomotor activity in the mazes and tests of activity in home cages indicated that the reduced anxiety observed in the mutant mice was not due to baseline locomotor activity differences among the genotypes. These results suggest that PKCγ be considered as one factor in the etiology of anxiety, perhaps via its post-synaptic regulation of GABAA and 5-HT2 receptors, two receptors implicated in the neurobiology of anxiety. Plenum Publishing Corporation, 2000 Anxiety nationallicence null mutant mice nationallicence γ-protein kinase C nationallicence Bowers Barbara aut Collins Allan aut Tritto Theresa aut Wehner Jeanne aut Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/2(2000-03-01), 111-121 0001-8244 30:2<111 2000 30 10519 https://doi.org/10.1023/A:1001951104208 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1001951104208 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bowers Barbara aut NATIONALLICENCE 700 1- Collins Allan aut NATIONALLICENCE 700 1- Tritto Theresa aut NATIONALLICENCE 700 1- Wehner Jeanne aut NATIONALLICENCE 773 0- Behavior Genetics Kluwer Academic Publishers-Plenum Publishers 30/2(2000-03-01), 111-121 0001-8244 30:2<111 2000 30 10519 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer