caa a22 4500 47580127X CHVBK 20180406123737.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s002689910005 doi (NATIONALLICENCE)springer-10.1007/s002689910005 Tauroursodeoxycholate and Cholestyramine Enhance Biliary Carcinogenesis in Hamsters [Elektronische Daten] [Yoshito Ikematsu, Tsutomu Tomioka, Tomoo Kitajima, Keiji Inoue, Yoshitsugu Tajima, Takashi Kanematsu] The aim of this study was to examine whether tauroursodeoxycholate (TUDC) and cholestyramine resin (CR) enhance biliary carcinogenesis in the hamster model. A cholecystoduodenostomy with dissection of the extrahepatic bile duct on the distal end of the common duct was performed on Syrian hamsters. The hamsters were then divided randomly into 3 groups: control group, TUDC-treated group, and CR-treated group. All animals received N-nitrosobis(2-oxopropyl)amine (BOP) to initiate pancreaticobiliary cancer. The experiment was terminated at week 16 and the number of neoplastic lesions was counted microscopically. In the TUDC group, the intrahepatic biliary carcinogenesis was more accelerated than that observed in the control group, but no promoting effect was seen in the pancreas, gallbladder, or extrahepatic bile duct. In the CR group, both the intrahepatic biliary and the gallbladder carcinogenesis were inhibited compared with that observed in the control group and the TUDC group. TUDC enhanced the intrahepatic bile duct carcinogenesis, whereas CR inhibited both the intrahepatic bile duct and the gallbladder carcinoma. Bile acids were suggested to promote biliary carcinoma in the hamster model. by the Société Internationale de Chirurgie, 2000 Ikematsu Yoshito Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut Tomioka Tsutomu Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut Kitajima Tomoo Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut Inoue Keiji Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut Tajima Yoshitsugu Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut Kanematsu Takashi Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 22-26 0364-2313 24:1<22 2000 24 268 https://doi.org/10.1007/s002689910005 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910005 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ikematsu Yoshito Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut NATIONALLICENCE 700 1- Tomioka Tsutomu Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut NATIONALLICENCE 700 1- Kitajima Tomoo Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut NATIONALLICENCE 700 1- Inoue Keiji Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut NATIONALLICENCE 700 1- Tajima Yoshitsugu Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut NATIONALLICENCE 700 1- Kanematsu Takashi Department of Surgery II, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 22-26 0364-2313 24:1<22 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer