caa a22 4500 475801326 CHVBK 20180406123738.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s002689910011 doi (NATIONALLICENCE)springer-10.1007/s002689910011 Clinicopathologic Correlation of p53 Protein Overexpression in Adenoma and Carcinoma of the Ampulla of Vater [Elektronische Daten] [Sun Hoo Park, Yong Il Kim, Yong Hyun Park, Sun Whe Kim, Ki Whan Kim, Yong Tae Kim, Woo Ho Kim] It has been well documented that ampullary carcinoma arises from a precancerous lesion, but there have been few studies concerning changes at the molecular level during the adenoma-carcinoma sequence. In this study, p53 overexpression during the progression of carcinoma was compared and the relation between p53 expression and prognosis was analyzed. Ninety-four cases of adenocarcinoma of the ampulla of Vater were reviewed histopathologically and examined for overexpression of p53 protein using the DO-7 (mouse monoclonal; DAKO, Glostrup, Denmark) antibody. The correlation of p53 overexpression with the existence of adenoma, clinical stage, histologic grade, and overall survival was investigated. The proportion of p53-positive cases among normal mucosa, adenoma, early stage carcinoma (I and II), advanced stage carcinoma (III and IV), and metastatic lesion was 0% (0/94), 14.3% (6/42), 32.3% (20/62), 53.1% (17/32), and 63.3% (19/30), respectively. The existence of adenoma or histologic grade of carcinoma did not correlate with p53 overexpression. The carcinoma having adenomatous component was more common in early stages (54.8% in stages I and II, 25% in stages III and IV; p= 0.006) and in well-differentiated carcinoma (p= 0.001). The existence of adenoma or p53 overexpression did not independently correlate with prognosis. In contrast, the p53 overexpressed group without adenoma showed a worse prognosis than the remaining patients (p= 0.0006) and this trend was still demonstrable when the groups were compared stage by stage. In ampullary carcinoma, p53 abnormality occurs during malignant transformation from the adenoma and continues during the tumor progression in carcinoma. The clinical prognosis of de novo carcinomas with p53 overexpression was worse than that of the remaining patients. by the Société Internationale de Chirurgie, 2000 Park Sun Hoo Department of Pathology, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut Kim Yong Il Department of Pathology, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut Park Yong Hyun Department of Surgery, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut Kim Sun Whe Department of Surgery, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut Kim Ki Whan Department of Surgery, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut Kim Yong Tae Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut Kim Woo Ho Department of Pathology, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 54-59 0364-2313 24:1<54 2000 24 268 https://doi.org/10.1007/s002689910011 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910011 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Sun Hoo Department of Pathology, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 700 1- Kim Yong Il Department of Pathology, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 700 1- Park Yong Hyun Department of Surgery, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 700 1- Kim Sun Whe Department of Surgery, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 700 1- Kim Ki Whan Department of Surgery, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 700 1- Kim Yong Tae Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 700 1- Kim Woo Ho Department of Pathology, Seoul National University College of Medicine, Yongon-dong 28, Seoul 110-799, Korea, KP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 54-59 0364-2313 24:1<54 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer