caa a22 4500 475801377 CHVBK 20180406123738.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s002689910004 doi (NATIONALLICENCE)springer-10.1007/s002689910004 Altered Bile Composition in the Gallbladder and Common Bile Duct of Patients with Anomalous Pancreaticobiliary Ductal Junction [Elektronische Daten] [Yuzuru Sugiyama, Hiroyasu Kobori, Kenichi Hakamada, Dai Seito, Mutsuo Sasaki] The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) has been well documented. Elevation of the secondary and free bile acid (FBA) concentrations is considered a risk factor for biliary carcinogenesis in these patients. Bile from the gallbladder and common bile duct in 12 patients with APBDJ was analyzed and compared with gallbladder bile from 19 patients with gastric cancer and a normal hepatobiliary tract. The concentrations of secondary bile acids were significantly lower in the APBDJ group than in the control group, and FBA concentrations were not detected in the gallbladder in either group. The lysolecithin (LL) in the phospholipid, which is produced from lecithin by activated phospholipase A2 in refluxing pancreatic juice, was significantly elevated in the APBDJ group. Elevation of the LL concentration in the bile is one of the factors for the development of biliary tract carcinoma in patients with APBDJ. by the Société Internationale de Chirurgie, 2000 Sugiyama Yuzuru Department of Nursing, Hirosaki University School of Allied Medical Sciences, 66-1 Hon-cho, Hirosaki, Aomori-ken 036-8564, Japan, JP aut Kobori Hiroyasu Department of Surgery, Aomori Municipal Hospital, 1-14-20 Katsuta, Aomori, Aomori-ken 030-0821, Japan, JP aut Hakamada Kenichi Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, Japan, JP aut Seito Dai Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, Japan, JP aut Sasaki Mutsuo Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, Japan, JP aut World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 17-21 0364-2313 24:1<17 2000 24 268 https://doi.org/10.1007/s002689910004 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910004 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugiyama Yuzuru Department of Nursing, Hirosaki University School of Allied Medical Sciences, 66-1 Hon-cho, Hirosaki, Aomori-ken 036-8564, Japan, JP aut NATIONALLICENCE 700 1- Kobori Hiroyasu Department of Surgery, Aomori Municipal Hospital, 1-14-20 Katsuta, Aomori, Aomori-ken 030-0821, Japan, JP aut NATIONALLICENCE 700 1- Hakamada Kenichi Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, Japan, JP aut NATIONALLICENCE 700 1- Seito Dai Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, Japan, JP aut NATIONALLICENCE 700 1- Sasaki Mutsuo Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 17-21 0364-2313 24:1<17 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer