caa a22 4500 475801415 CHVBK 20180406123738.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s002689910019 doi (NATIONALLICENCE)springer-10.1007/s002689910019 Muscular Performance and Fatigue in Primary Hyperparathyroidism [Elektronische Daten] [Søren R. Deutch, Martin B. Jensen, Peer M. Christiansen, Ib HessovD.M.Sc.] The purpose of this study was to evaluate changes in muscular strength and endurance, work capacity, and subjective fatigue following surgical treatment of primary hyperparathyroidism (pHPT), and to assess whether changes in muscular function were due to changes in activation of the muscles. A prospective consecutive study design was used, and patients surgically treated for nontoxic goiter served as controls. Nineteen female patients with mild to moderate pHPT and 20 controls were included. Maximal isometric handgrip and quadriceps strength, quadriceps endurance (intermittent stimulation), and quadriceps activation (superimposed twitch technique) were used for evaluation of muscular function. All patients were operated on successfully. Knee extension strength increased by 17 ± 17% (mean ± SD; p= 0.0004) in the patients, whereas no change was observed in the controls. The relative strength increase correlated positively to patient age at operation (r= 0.52, p= 0.02). Handgrip strength, quadriceps endurance, and general work capacity did not change in any group after operation. Subjective fatigue was preoperatively higher in patients than in controls (p= 0.01), and decreased postoperatively to the level of controls. In conclusion, women with pHPT increase knee extension force after parathyroidectomy as a result of increased force generation capacity of the muscle. If change in physical performance is a determinant for change in subjective fatigue in pHPT after operation, then change in strength of the quadriceps muscle seems to be of primary importance, whereas handgrip strength, muscular endurance, and work capacity do not seem to be important. The cause of the increasing strength benefit with increasing age at operation as found in this study needs further investigation. by the Société Internationale de Chirurgie, 2000 Deutch Søren R. Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut Jensen Martin B. Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut Christiansen Peer M. Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut HessovD.M.Sc. Ib Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 102-107 0364-2313 24:1<102 2000 24 268 https://doi.org/10.1007/s002689910019 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910019 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deutch Søren R. Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut NATIONALLICENCE 700 1- Jensen Martin B. Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut NATIONALLICENCE 700 1- Christiansen Peer M. Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut NATIONALLICENCE 700 1- HessovD.M.Sc Ib Department of Surgery L, University Hospital of Aarhus, Tage Hansens Gade #2, DK-8000 Aarhus C, Denmark, DK aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/1(2000-01-01), 102-107 0364-2313 24:1<102 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer