caa a22 4500 475801431 CHVBK 20180406123738.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002689910112 doi (NATIONALLICENCE)springer-10.1007/s002689910112 Manipulations of the Metabolic Response for Management of Patients with Severe Surgical Illness: Review [Elektronische Daten] [A.B. Connolly, D.R. Vernon] Abstract.: The metabolic response to severe surgical illness is complex and varied. Much recent laboratory and clinical research has focused on increasing our understanding of the metabolic response and the development of new therapies designed to modify this response. Antiinflammatory agents can target harmful aspects of the metabolic response; the immune system can be stimulated; and anabolic factors can be used in an attempt to enhance recovery. The nutritional support of the surgical patient remains crucial, but the effects of new additives are being studied in a variety of surgical conditions. As yet, few of these "novel” agents have found an established role in the management of surgical patients. This review focuses on many "novel” agents or those that do not yet have a clearly defined role in surgical illness. Clinical trials in the areas of severe sepsis, major surgical trauma, and major elective surgery have been emphasized. 2000 by the Société Internationale de Chir, 2000 Connolly A.B. Department of Surgery, University of Auckland, Private Bag, Auckland, New Zealand, New Zealand aut Vernon D.R. Department of Surgery, University of Auckland, Private Bag, Auckland, New Zealand, New Zealand aut World Journal of Surgery Springer-Verlag 24/6(2000-06-01), 696-704 0364-2313 24:6<696 2000 24 268 https://doi.org/10.1007/s002689910112 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910112 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Connolly A.B. Department of Surgery, University of Auckland, Private Bag, Auckland, New Zealand, New Zealand aut NATIONALLICENCE 700 1- Vernon D.R. Department of Surgery, University of Auckland, Private Bag, Auckland, New Zealand, New Zealand aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/6(2000-06-01), 696-704 0364-2313 24:6<696 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer