caa a22 4500 475801539 CHVBK 20180406123738.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002689910110 doi (NATIONALLICENCE)springer-10.1007/s002689910110 Disordered Metabolic Response with Cancer and Its Management [Elektronische Daten] [Matthew D. Barber, James A. Ross, Kenneth C.H. Fearon] Abstract.: The metabolic changes in cancer cachexia appear to be mediated by a complex network of proinflammatory cytokines, neuroendocrine hormones, neurotransmitters, eicosanoids, and tumor-derived factors produced by the body in response to the tumor and by the tumor itself. The relative importance of these various mediator pathways in relation to either the anorexia or hypermetabolism associated with weight loss in cancer remains to be fully elucidated. Our current understanding suggests that proinflammatory mediators may indeed be a valid target for therapeutic intervention. Trials attempting to modify the inflammatory response to cancer with the hope of improving appetite and reversing catabolism and perhaps thereby improving quality of life and survival are currently underway. 2000 by the Société Internationale de Chir, 2000 Barber Matthew D. University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland, UK EH3 9YW, UK aut Ross James A. University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland, UK EH3 9YW, UK aut Fearon Kenneth C.H. University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland, UK EH3 9YW, UK aut World Journal of Surgery Springer-Verlag 24/6(2000-06-01), 681-689 0364-2313 24:6<681 2000 24 268 https://doi.org/10.1007/s002689910110 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910110 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barber Matthew D. University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland, UK EH3 9YW, UK aut NATIONALLICENCE 700 1- Ross James A. University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland, UK EH3 9YW, UK aut NATIONALLICENCE 700 1- Fearon Kenneth C.H. University Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland, UK EH3 9YW, UK aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/6(2000-06-01), 681-689 0364-2313 24:6<681 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer