caa a22 4500 475801563 CHVBK 20180406123738.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002689910108 doi (NATIONALLICENCE)springer-10.1007/s002689910108 Metabolic Management of Severe Acute Pancreatitis [Elektronische Daten] [John A. Windsor, Hisham Hammodat] Abstract.: The metabolic management of severe acute pancreatitis involves early identification of patients with severe pancreatitis, aggressive fluid resuscitation, organ support, and careful monitoring in an intensive care environment. Recent evidence has helped to define the roles of enteral feeding, prophylactic antibiotics, endoscopic retrograde cholangiopancreatography, computed tomography, and fine-needle aspiration for bacteriology. The most difficult decision in the management of these patients is whether surgery is required and which of the complementary approaches to necrosectomy and drainage is appropriate. Key metabolic events in the acinar cell, pancreas, and intestines are now being unraveled, as is the basis for the systemic manifestations and organ dysfunction associated with pancreatitis. This gives hope for the development of more specific metabolic interventions, which will likely target the maintenance of intestinal integrity and function, preservation of pancreatic microcirculation, and balanced modulation of the inflammatory response. 2000 by the Société Internationale de Chir, 2000 Windsor John A. Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, New Zealand aut Hammodat Hisham Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, New Zealand aut World Journal of Surgery Springer-Verlag 24/6(2000-06-01), 664-672 0364-2313 24:6<664 2000 24 268 https://doi.org/10.1007/s002689910108 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910108 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Windsor John A. Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, New Zealand aut NATIONALLICENCE 700 1- Hammodat Hisham Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, New Zealand aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/6(2000-06-01), 664-672 0364-2313 24:6<664 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer