caa a22 4500 475801725 CHVBK 20180406123739.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002680010143 doi (NATIONALLICENCE)springer-10.1007/s002680010143 Histoclinical Analysis of Early Colorectal Cancer [Elektronische Daten] [Young Jin Park, Woo-Ho Kim, Sung Suk Paeng, Jae-Gahb Park] To evaluate the clinicopathologic characteristics of early colorectal cancer (ECC), histopathologic and clinical features of 90 ECC patients who underwent surgical resection (not including the endoscopic polypectomized cases) and 1704 patients with advanced colorectal cancer were analyzed. Smaller size, better histologic differentiation, less lymph node (LN) metastasis, and better clinical outcome were observed in those with ECC than in patients with more advanced lesions. LN metastasis was found in 5 patients with ECC among the 56 patients who underwent bowel resection (8.9%). Tumors with LN metastasis were more frequently associated with deep submucosal invasion, absence of an adenomatous component within the tumor, sessile configuration, and lymphovascular invasion. Tumors showing deep submucosal layer invasion were associated with a more unfavorable histologic grade, lymphovascular invasion, LN metastasis, sessile morphology, and absence of an adenomatous component within the tumor. Recurrence was observed in two patients who underwent local excision for their submucosal cancer. One of the patients was salvaged after bowel resection, but one patient died of distant metastasis. From our data analysis and literature review, extensive submucosal invasion, lymphovascular invasion, sessile configuration, and tumors with no adenomatous component should be considered high risk factors for LN metastasis and recurrence after limited therapy. Société Internationale de Chirurgie, 2000 Park Young Jin Department of Surgery, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul 110-744, Korea aut Kim Woo-Ho Department of Pathology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul, 110-744, Korea aut Paeng Sung Suk Department of Pathology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul, 110-744, Korea aut Park Jae-Gahb Department of Surgery, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul 110-744, Korea aut World Journal of Surgery Springer-Verlag 24/9(2000-09-01), 1029-1035 0364-2313 24:9<1029 2000 24 268 https://doi.org/10.1007/s002680010143 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010143 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Young Jin Department of Surgery, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul 110-744, Korea aut NATIONALLICENCE 700 1- Kim Woo-Ho Department of Pathology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul, 110-744, Korea aut NATIONALLICENCE 700 1- Paeng Sung Suk Department of Pathology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul, 110-744, Korea aut NATIONALLICENCE 700 1- Park Jae-Gahb Department of Surgery, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-gu, Seoul 110-744, Korea aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/9(2000-09-01), 1029-1035 0364-2313 24:9<1029 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer