caa a22 4500 475801814 CHVBK 20180406123739.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002680010152 doi (NATIONALLICENCE)springer-10.1007/s002680010152 Jass Jeremy R. Department of Pathology, The University of Queensland Medical School, Herston Road, Herston Queensland 4006, Australia aut Histopathology of Early Colorectal Cancer [Elektronische Daten] [Jeremy R. Jass] The histopathologic spectrum of early colorectal cancer (ECC) is compared from the Western and Japanese perspective. In the West, most ECC presents as a malignant adenoma, whereas superficial ECC with no adenomatous component is well described in the Japanese literature. Furthermore, superficial ECC is thought to progress rapidly and disseminate early. The discrepant viewpoints are considered in the light of different approaches to histopathologic interpretation. Lesions reported by Japanese pathologists as superficial carcinomas limited to the mucosa are diagnosed as flat adenomas in the West. In one Japanese series only 4 of 218 (1.8%) flat or small sessile neoplasms removed by endoscopic mucosal resection were associated with submucosal invasion by carcinoma. Therefore superficial ECC with submucosal spread is uncommon. Most ECC in hereditary nonpolyposis colorectal cancer evolves through the adenoma—carcinoma pathway (including flat adenoma). However, adenoma removal in the context of population-based screening programs has not lowered the incidence of colorectal cancer; flat colorectal neoplasia may be important in clinical practice. Société Internationale de Chirurgie, 2000 World Journal of Surgery Springer-Verlag 24/9(2000-09-01), 1016-1021 0364-2313 24:9<1016 2000 24 268 https://doi.org/10.1007/s002680010152 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010152 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Jass Jeremy R. Department of Pathology, The University of Queensland Medical School, Herston Road, Herston Queensland 4006, Australia aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/9(2000-09-01), 1016-1021 0364-2313 24:9<1016 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer