caa a22 4500 475801881 CHVBK 20180406123739.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s002680010123 doi (NATIONALLICENCE)springer-10.1007/s002680010123 Murray Joseph E. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Children's Hospital, 108 Abbott Road, Wellesley Hills, Massachusetts 02481, USA, US aut Surgeon Scientist [Elektronische Daten] [Joseph E. Murray] Abstract.: The origins and development of the renal transplant program at the Peter Bent Brigham Hospital (now the Brigham and Women's Hospital) from the late 1940s to the present are reviewed. The program was initiated as a effort to understand hypertension as a cause of renal failure. The initial transplants were unmodified allogeneic grafts placed in the thigh, followed by extensive laboratory experiments on dogs. This research culminated with the first successful human transplant of a kidney between identical twins in 1954. In 1959 the first successful fraternal allogeneic graft was accomplished as part of a protocol utilizing total body irradiation and bone marrow replacement. Finally, with the development of immunosuppressive drugs, we were able to transplant a cadaveric kidney successfully in 1962. This was a major impetus in the study of organ transplantation worldwide, which currently involves kidneys, liver, heart, pancreas, heart/lung, and bone marrow. by Société Internionale de Chirurgie, 2000 World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 757-758 0364-2313 24:7<757 2000 24 268 https://doi.org/10.1007/s002680010123 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010123 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Murray Joseph E. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Children's Hospital, 108 Abbott Road, Wellesley Hills, Massachusetts 02481, USA, US aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 757-758 0364-2313 24:7<757 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer