caa a22 4500 475801911 CHVBK 20180406123739.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s002680010126 doi (NATIONALLICENCE)springer-10.1007/s002680010126 BrentB.Sc. Leslie Baruch 30 Hugo Road, Tufnell Park, London N19 5EU, UK, GB aut Tolerance and Its Clinical Significance [Elektronische Daten] [Leslie Baruch BrentB.Sc.] Abstract.: Several aspects of fetally or neonatally induced tolerance are briefly considered, and a variety of strategies for the induction of specific tolerance in adult animals or patients are discussed. They include the following: (1) augmentation of organ transplantation with donor-specific bone marrow; (2) the "prope” tolerance postulated by R.Y. Calne following treatment of kidney transplant recipients with a powerful monoclonal antibody; (3) linked epitope suppression, a form of specific tolerance for fully allogeneic haplotypes that can be induced in adult animals with a single major histocompatibility complex (MHC) epitope provided it is presented on the same antigen-presenting cells as the other MHC antigens; (4) allogeneic mixed chimerism, induced in experimental animals by the inoculation of allogeneic bone marrow into adult animals that had been subjected to a nonmyelosuppressive regimen, avoiding whole body irradiation; (5) several other approaches, viz., total lymphoid irradiation with bone marrow infusion, intrathymically induced tolerance, and the still rather mysterious case of the maternally noninherited HLA antigens of siblings. All or some of these strategies may yet come into their own in clinical transplantation, as the induction of specific tolerance must still be regarded as the most satisfactory solution to the problems of allogeneic, and perhaps xenogeneic, transplantation. by Société Internionale de Chirurgie, 2000 World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 787-792 0364-2313 24:7<787 2000 24 268 https://doi.org/10.1007/s002680010126 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010126 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- BrentB.Sc Leslie Baruch 30 Hugo Road, Tufnell Park, London N19 5EU, UK, GB aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 787-792 0364-2313 24:7<787 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer