caa a22 4500 47580192X CHVBK 20180406123739.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s002680010135 doi (NATIONALLICENCE)springer-10.1007/s002680010135 Efficacy and Safety of Preoperative Lobar or Segmental Ablation via Transarterial Administration of Ethiodol and Ethanol Mixture for Treatment of Hepatocellular Carcinoma: Clinical Study [Elektronische Daten] [Yu-fan Cheng, Zuxing Kan, Chao-long Chen, Tung-liang Huang, Tai-yi Chen, Bor-yau Yang, Sheung-fat Ko, Tze-yu Lee] Abstract.: Transarterial embolization (TAE) using various thrombotic substances for unresectable hepatocellular carcinoma (HCC) performed on many patients has resulted in a better survival rate. We evaluated the efficacy and clinical safety of using an Ethiodol-ethanol mixture as the embolizer for treatment of HCC and the possibility of a surgical approach for inoperable tumors after TAE. Twenty patients with HCC who underwent TAE and tumor resection were included in the study. Initially, eight had increased retention rate of indocyanine green dye via intravenous injection (0.5 mg/kg) at 15 minutes (ICGR15), and six had an insufficient residual volume that precluded them from undergoing tumor resection. TAE was performed by slowly infusing the mixture of Ethiodol and ethanol into the artery supplying the tumor until dual hepatic artery and portal vein embolization was achieved. Serum levels of alanine aminotransferase increased after embolization, but all biochemistry studies reverted to normal within 2 weeks. A decreased tumor size (n= 15), improved ICG (n= 8), and increased volume of the nonembolized lobe (n= 10) were noted. The operations performed were right lobectomy (n= 11), extended right lobectomy (n= 3), left lobectomy (n= 2), extended left lobectomy (n= 2), and wedge resection (n= 2), which included patients who did not want to undergo major hepatectomy. Complete tumor necrosis was found in seven cases. All patients survived with no associated complications. The 1-year survival rate was 95%. Transarterial Ethiodol and ethanol administration creating dual hepatic artery and portal vein embolization was a safe and efficacious method for treating HCC. It effectively decreases tumor size, causes compensatory hepatic hypertrophy, and improves the ICGR15, which allows a wider range of patients to undergo liver surgery and achieve better survival. by Société Internionale de Chirurgie, 2000 Cheng Yu-fan Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut Kan Zuxing Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, 515 Holcombe Boulevard, Houston, Texas 77030, USA, US aut Chen Chao-long Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut Huang Tung-liang Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut Chen Tai-yi Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut Yang Bor-yau Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut Ko Sheung-fat Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut Lee Tze-yu Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 844-850 0364-2313 24:7<844 2000 24 268 https://doi.org/10.1007/s002680010135 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010135 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheng Yu-fan Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 700 1- Kan Zuxing Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, 515 Holcombe Boulevard, Houston, Texas 77030, USA, US aut NATIONALLICENCE 700 1- Chen Chao-long Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 700 1- Huang Tung-liang Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 700 1- Chen Tai-yi Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 700 1- Yang Bor-yau Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 700 1- Ko Sheung-fat Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 700 1- Lee Tze-yu Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123 Tai Pei Road, Kaohsiung Hsien, Taiwan, TW aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 844-850 0364-2313 24:7<844 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer