caa a22 4500 475801989 CHVBK 20180406123739.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s002680010133 doi (NATIONALLICENCE)springer-10.1007/s002680010133 Terasaki Paul I. Department of Surgery, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095, USA, US aut Longmire Lecture: My 50 Years at the University of California, Los Angeles [Elektronische Daten] [Paul I. Terasaki] Abstract.: The main concept driving my work has been the humoral theory of immunity to allografts. It led to the development of the microlymphocytotoxicity test, which is used to look for the relevant transplant antigens using alloantisera. Using alloantibodies produced by pregnancies, the HLA system was defined through a series of international histocompatibility workshops. It was then shown that the HLA system was important for matching donors and recipients for bone marrow transplants and organ transplants. More than 6000 HLA-matched kidney transplants from cadaver donors have now been shared in the United States. HLA antigens were found to be of importance in anthropologic and disease susceptibility studies. Currently HLA antibodies are being studied intensively to determine their role in chronic rejection. If it is proven that these antibodies trigger intimal proliferation, occluding arterioles, HLA antibodies will become essential to the monitoring of chronic rejection. by Société Internionale de Chirurgie, 2000 World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 828-833 0364-2313 24:7<828 2000 24 268 https://doi.org/10.1007/s002680010133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010133 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Terasaki Paul I. Department of Surgery, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095, USA, US aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/7(2000-07-01), 828-833 0364-2313 24:7<828 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer