caa a22 4500 475802276 CHVBK 20180406123740.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002680010270 doi (NATIONALLICENCE)springer-10.1007/s002680010270 Growth Factors in Clinical Practice [Elektronische Daten] [Zhu-Ming Jiang, Douglas W. Wilmore, Wei Liu, Yue-Wu Liu] Growth factors enhance protein synthesis and thus reduce the catabolic response to injury. As a result of bioengineering and new manufacturing techniques several anabolic agents have become available for clinical use and have been evaluated in surgical patients with catabolic illness. Data support the anabolic effects of growth home in such patients, but its expense and possible deleterious effects during the acute phase of illness limit its use to selected patient groups. Insulin-like growth factor-1 has also been studied, but specific indications for its use have not been identified in catabolic patients. Testosterone and derivatives of this hormone exert anabolic effects, but few randomized trials include catabolic surgical patients, and higher doses of some derivative compounds are associated with hepatic dysfunction. Nonetheless, as we move into the future, studies will determine the specific doses for administration of these and other anabolic factors in specific patient groups. Anabolic therapy will shorten the length of therapy and improve the outcome in the future. Société Internationale de Chirurgie, 2000 Jiang Zhu-Ming aut Wilmore Douglas W. aut Liu Wei aut Liu Yue-Wu aut World Journal of Surgery Springer-Verlag 24/12(2000-12-01), 1514-1518 0364-2313 24:12<1514 2000 24 268 https://doi.org/10.1007/s002680010270 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010270 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jiang Zhu-Ming aut NATIONALLICENCE 700 1- Wilmore Douglas W. aut NATIONALLICENCE 700 1- Liu Wei aut NATIONALLICENCE 700 1- Liu Yue-Wu aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/12(2000-12-01), 1514-1518 0364-2313 24:12<1514 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer