caa a22 4500 475802292 CHVBK 20180406123740.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002680010281 doi (NATIONALLICENCE)springer-10.1007/s002680010281 Pancreastatin Plasma Levels in Patients with Primary Hyperparathyroidism [Elektronische Daten] [Anders Bergenfelz, Lena Luts, Tine Børglum Jensen, Frank Sundler] Pancreastatin, a C-terminally amidated peptide derived from chromogranin A, is known to inhibit insulin secretion, pancreatic enzyme release, and gastric acid secretion. It also inhibits parathyroid hormone (PTH) secretion in animals. The physiologic and clinical relevance of pancreastatin in humans, however, is not known. Because pancreastatin has been found in parathyroid adenomas, we investigated the plasma levels in patients with primary hyperparathyroidism (pHPT). Thirteen patients operated on for solitary parathyroid adenoma were investigated. Plasma levels of pancreastatin and serum levels of ionized calcium and intact PTH were measured before and 6 weeks after operation. In 10 patients the levels were also monitored before and 60 minutes after adenoma excision. The adenomas were investigated for pancreastatin immunoreactivity by immunocytochemistry. The median weight of the excised parathyroid adenoma was 0.64 g (range 0.07-2.00 g). Cells displaying pancreastatin immunoreactivity were present in all adenomas examined and varied in number and immunostaining intensity among and within the adenomas. Intraoperatively, after adenoma excision the levels of PTH and pancreastatin declined (p < 0.01), whereas the levels of ionized calcium did not change (p= 0.96). At the 6-week follow-up the levels of ionized calcium and PTH had decreased compared to the preoperative levels (p < 0.01), and all patients were normocalcemic. In contrast, the pancreastatin levels were not changed (14.5 ± 6.1 pmol/L preoperatively vs. 12.8 ± 11.2 pmol/L 6 weeks postoperatively; p= 0.12). In patients with pHPT, pancreastatin is likely to be produced by the parathyroid adenoma. The changes in pancreastatin levels immediately after surgery warrant further investigation. Société Internationale de Chirurgie, 2000 Bergenfelz Anders Department of Surgery, Lund University Hospital, S-221 85 Lund, Sweden, SE aut Luts Lena Department of Physiology and Neuroscience Section for Neuroendocrine Cell Biology, University of Lund, S-221 85 Lund, Sweden, SE aut Børglum Jensen Tine Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, DK aut Sundler Frank Department of Physiology and Neuroscience Section for Neuroendocrine Cell Biology, University of Lund, S-221 85 Lund, Sweden, SE aut World Journal of Surgery Springer-Verlag 24/12(2000-12-01), 1579-1583 0364-2313 24:12<1579 2000 24 268 https://doi.org/10.1007/s002680010281 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010281 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergenfelz Anders Department of Surgery, Lund University Hospital, S-221 85 Lund, Sweden, SE aut NATIONALLICENCE 700 1- Luts Lena Department of Physiology and Neuroscience Section for Neuroendocrine Cell Biology, University of Lund, S-221 85 Lund, Sweden, SE aut NATIONALLICENCE 700 1- Børglum Jensen Tine Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, DK aut NATIONALLICENCE 700 1- Sundler Frank Department of Physiology and Neuroscience Section for Neuroendocrine Cell Biology, University of Lund, S-221 85 Lund, Sweden, SE aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/12(2000-12-01), 1579-1583 0364-2313 24:12<1579 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer