caa a22 4500 475802349 CHVBK 20180406123741.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002689910057 doi (NATIONALLICENCE)springer-10.1007/s002689910057 Measurement of Serum Hyaluronate as a Predictor of Human Liver Failure after Major Hepatectomy [Elektronische Daten] [Shinichi Yachida, Hisao Wakabayashi, Yasutaka Kokudo, Fuminori Goda, Setsuo Okada, Takashi Maeba, Hajime Maeta] Serum hyaluronate can be used as an index of hepatic sinusoidal endothelial cell function. This study was designed to evaluate its application as a predictor of liver failure after major hepatectomy. Thirty-six patients who underwent right liver lobectomy after percutaneous transhepatic right branch portal vein embolization were divided into two groups based on their postoperative clinical course (groups 1 and 2, with and without postoperative liver failure, n= 6 and n= 30, respectively). We serially measured serum hyaluronate levels using a sandwich binding protein assay system before and after hepatectomy and determined relations with progression of the underlying chronic liver disorder, portal venous pressure, and liver growth of the left lobe after portal embolization. Serum hyaluronate levels were significantly elevated, in line with the degree of severity of the underlying chronic liver disorder, and correlated well with the portal venous pressure and the hypertrophic ratio of the left lobe subsequent to portal embolization. Serum hyaluronate levels in group 1 were significantly higher than those in group 2 before surgery and increased steeply during the early period after hepatectomy. These results suggest that the serum hyaluronate reflects the hepatic functional reserve, and serial measurement of this parameter after hepatectomy can serve as a simple indicator for early detection of posthepatectomy liver failure. by the Société Internationale de Chirurgie, 2000 Yachida Shinichi First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut Wakabayashi Hisao First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut Kokudo Yasutaka First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut Goda Fuminori First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut Okada Setsuo First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut Maeba Takashi First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut Maeta Hajime First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut World Journal of Surgery Springer-Verlag 24/3(2000-03-01), 359-364 0364-2313 24:3<359 2000 24 268 https://doi.org/10.1007/s002689910057 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910057 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yachida Shinichi First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 700 1- Wakabayashi Hisao First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 700 1- Kokudo Yasutaka First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 700 1- Goda Fuminori First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 700 1- Okada Setsuo First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 700 1- Maeba Takashi First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 700 1- Maeta Hajime First Department of Surgery, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/3(2000-03-01), 359-364 0364-2313 24:3<359 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer