caa a22 4500 475802489 CHVBK 20180406123741.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002689910061 doi (NATIONALLICENCE)springer-10.1007/s002689910061 Surgical Results in Patients with Hepatitis B-related Hepatocellular Carcinoma and Positive Hepatitis B Early Antigen [Elektronische Daten] [Jen-Hao Chen, Gar-Yang Chau, Wing-Yiu Lui, Shyh-Haw Tsay, Kuang-Liang King, Che-Chuan Loong, Cheng-Yuan Hsia, Chew-Wen Wu] Hepatitis B virus (HBV) infection is the major risk factor in the pathogenesis of hepatocellular carcinoma (HCC). Patients who are positive for hepatitis B early antigen (HBeAg) have active liver disease. The present study aimed to evaluate the possible role of HBeAg in patients with resectable HCC. A series of 249 HCC patients with complete preoperative hepatitis marker who had undergone potentially curative resection were enrolled. Patients with hepatitis C virus infection were excluded. Of these patients, 27 were positive for hepatitis B surface antigen (HBsAg) and HBeAg (group I), 171 were positive for HBsAg and negative for HBeAg (group II), and 51 were negative for hepatitis B markers (group III). The clinicopathologic features and postoperative survivals were compared among the three groups. The prevalence of HBeAg was 10.8%. Group I patients were significantly younger and had worse liver function, smaller tumors, and a higher incidence of liver cirrhosis and chronic active hepatitis than those in groups II and III. No increase in tumor invasiveness was noted in group I patients. The operative morbidity, mortality, and postresection survival were comparable among the three groups. Our findings indicated that HBeAg positivity is not a negative factor for resection in HCC patients and has no significant influence on postresection survival. by the Société Internationale de Chirurgie, 2000 Chen Jen-Hao Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut Chau Gar-Yang Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut Lui Wing-Yiu Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut Tsay Shyh-Haw Department of Pathology, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut King Kuang-Liang Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut Loong Che-Chuan Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut Hsia Cheng-Yuan Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut Wu Chew-Wen Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut World Journal of Surgery Springer-Verlag 24/3(2000-03-01), 383-388 0364-2313 24:3<383 2000 24 268 https://doi.org/10.1007/s002689910061 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910061 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Jen-Hao Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Chau Gar-Yang Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Lui Wing-Yiu Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Tsay Shyh-Haw Department of Pathology, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- King Kuang-Liang Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Loong Che-Chuan Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Hsia Cheng-Yuan Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Wu Chew-Wen Department of Surgery, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taipei 217, Taiwan, Republic of China, CN aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/3(2000-03-01), 383-388 0364-2313 24:3<383 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer