caa a22 4500 475802543 CHVBK 20180406123741.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002680010248 doi (NATIONALLICENCE)springer-10.1007/s002680010248 Relation between Gastroduodenal Interdigestive Migrating Motor Complex and Postoperative Gastrointestinal Symptoms before and after Cisapride Therapy following Distal Gastrectomy for Early Gastric Cancer [Elektronische Daten] [Ryouichi Tomita, Katsuhisa Tanjoh, Shigeru Fujisaki, Masahiro Fukuzawa] Abstract.: A total of 30 patients (18 men, 12 women; 43-79 years, mean 58.9 years) 1.0 to 1.5 years (mean 1.25 years) after distal gastrectomy for early gastric cancer (Billorth I, D2 lymph node dissection, curability A) were divided into two groups based on the occurrence of interdigestive migrating motor complex (IMMC) phase III (pIII) from the duodenum and their postoperative gastrointestinal symptoms. They were compared before and after cisapride therapy (at an oral dose of 7.5 mg/day for 3 months). Results were as follows. Before cisapride therapy: (1) Patients in the IMMC-pIII-positive group (n= 20) had more appetite and ate more food with less decrease in body weight than those in the IMMC-pIII-negative group (n= 10); (2) patients in the IMMC-pIII-positive group clearly had fewer symptoms, such as early dumping (systemic) symptoms, symptoms of reflux esophagitis (e.g., heartburn, feeling of regurgitation, difficult swallowing), nausea, abdominal pain, diarrhea, abdominal distension, and borborygmus, than the IMMC-pIII-negative group. After cisapride therapy: eight patients (80%) in the IMMC-pIII-negative group became IMMC-pIII-positive, and their appetite and food consumption were obviously improved; body weight increased in six patients (60%), with alleviation of other abdominal symptoms and disappearance of the early dumping syndrome. These results showed a more satisfactory condition in regard to gastrointestinal symptoms in the IMMC-pIII-positive group than in the IMMC-pIII-negative group. It is concluded that cisapride therapy results in the occurrence of IMMC-pIII and subsequently alleviates various abdominal symptoms, contributing to the improved postoperative gastrointestinal condition of patients after gastrectomy. by Société Internationale de Chirurgie, 2000 Tomita Ryouichi First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut Tanjoh Katsuhisa First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut Fujisaki Shigeru First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut Fukuzawa Masahiro First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1250-1257 0364-2313 24:10<1250 2000 24 268 https://doi.org/10.1007/s002680010248 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010248 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomita Ryouichi First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut NATIONALLICENCE 700 1- Tanjoh Katsuhisa First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut NATIONALLICENCE 700 1- Fujisaki Shigeru First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut NATIONALLICENCE 700 1- Fukuzawa Masahiro First Department of Surgery, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashi-ku, Tokyo 173 0032, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1250-1257 0364-2313 24:10<1250 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer