caa a22 4500 47580256X CHVBK 20180406123741.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002680010198 doi (NATIONALLICENCE)springer-10.1007/s002680010198 Namiki Mikio Department of Urology, Kanazawa University School of Medicine, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan, JP aut Genetic Aspects of Male Infertility [Elektronische Daten] [Mikio Namiki] Abstract : Genetic factors affecting male infertility are reviewed. Male infertility is classified under four general causes: spermatogenic disorder, obstruction of the seminal tract, inflammation, sexual disorders. Idiopathic spermatogenic disorder accounts for more than 50% of all of them. The cause of spermatogenic disorder is not yet identified. In recent years it has become obvious that some of the crucial genes expressed during male germ cell differentiation exist on the long arm of Y chromosome (Yq). Identification of a gene specifically involved in sperm production could provide a more rational basis for the treatment of male infertility. In this paper I review the history of azoospermia factor (AZF), which is involved in sperm production, and describe our research on a novel AZF candidate. In 1993 Ma and coworkers isolated an AZF candidate named YRRM; and in 1995 Reijo and coworkers reported another AZF candidate known as DAZ. The existence of additional genes on Yq is strongly suspected. We are now seeking a novel AZF candidate using positional cloning and an exon trapping method. The candidate should be included in the YAC yOX21 covering microdeleted portion of Yq found by analyzing DNA obtained from many infertile men. Several unknown sequences were identified by the analysis. Ongoing studies on AZF will prove useful in the diagnosis and treatment of male infertility. by Société Internationale de Chirurgie, 2000 World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1176-1179 0364-2313 24:10<1176 2000 24 268 https://doi.org/10.1007/s002680010198 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010198 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Namiki Mikio Department of Urology, Kanazawa University School of Medicine, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1176-1179 0364-2313 24:10<1176 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer