caa a22 4500 475802578 CHVBK 20180406123741.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002680010200 doi (NATIONALLICENCE)springer-10.1007/s002680010200 Molecular Analysis of Mechanisms Regulating Drug Sensitivity andthe Development of New Chemotherapy Strategies for Genitourinary Carcinomas [Elektronische Daten] [Seiji Naito, Hirofumi Koga, Akira Yokomizo, Naotaka Sakamoto, Shuji Kotoh, Michitaka Nakashima, Akira Kiue, Michihiko Kuwano] Abstract : The emergence of drug-resistant tumors during treatment remains one of the major obstacles in cancer chemotherapy. Overexpression of P-glycoprotein encoded by the multidrug resistance 1 (MDR1) gene or multidrug resistance-associated protein (MRP) (or both) and decreased expression of DNA topoisomerase II are responsible for expression of the multidrug resistance (MDR) phenotype. The expression of P-glycoprotein is also often observed in untreated cancers showing spontaneous MDR, such as renal cell carcinoma. Regarding cisplatin resistance, decreased cisplatin accumulation, an increase in cisplatin detoxification by glutathione-related enzymes or metallothionein (or both), and increased repair of DNA damage are all considered to play an important role. The combination of reversal agents targeting such drug resistance markers may be a way to improve the outcome of chemotherapy. Regarding the presently available reversal agents, however, clinically relevant chemosensitizing doses cannot be given to humans without inducing significant toxicity. The development of new agents that reverse drug resistance without causing significant toxicity and their clinical application based on the mechanisms regulating drug sensitivity may therefore be a potentially effective new treatment strategy for genitourinary carcinomas. by Société Internationale de Chirurgie, 2000 Naito Seiji Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut Koga Hirofumi Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut Yokomizo Akira Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut Sakamoto Naotaka Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut Kotoh Shuji Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut Nakashima Michitaka Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut Kiue Akira Omiya Research Laboratory, Nikken Chemicals Co., 1-346 Kitabukuro, Omiya 330-0835, Japan, JP aut Kuwano Michihiko Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1183-1186 0364-2313 24:10<1183 2000 24 268 https://doi.org/10.1007/s002680010200 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010200 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naito Seiji Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 700 1- Koga Hirofumi Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 700 1- Yokomizo Akira Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 700 1- Sakamoto Naotaka Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 700 1- Kotoh Shuji Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 700 1- Nakashima Michitaka Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 700 1- Kiue Akira Omiya Research Laboratory, Nikken Chemicals Co., 1-346 Kitabukuro, Omiya 330-0835, Japan, JP aut NATIONALLICENCE 700 1- Kuwano Michihiko Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1183-1186 0364-2313 24:10<1183 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer