caa a22 4500 475802705 CHVBK 20180406123742.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002680010195 doi (NATIONALLICENCE)springer-10.1007/s002680010195 Gardiner Robert A. Department of Surgery, University of Queensland, Royal Brisbane Hospital, Herston 4029, Australia, AU aut Molecular and Reconstructive Urology: A Coming Together [Elektronische Daten] [Robert A. Gardiner] Abstract : Appreciation of the clinical utility of the protein product of kallikrein gene 3, prostate-specific antigen (PSA), has resulted in earlier diagnosis of prostate cancer and an associated increase in the number of radical prostatectomies performed. A consequence of this change in surgical practice has been an improved understanding of sphincter anatomy and methods for sphincter preservation, which in turn have led to enhanced popularity for orthotopic urinary diversion for invasive bladder cancer. In this paper, molecular and basic science research being undertaken in an to attempt to overcome problems and limitations of the PSA/transrectal ultrasonographic biopsy approach to diagnosis are discussed. Also detailed are (1) the development of a bladder acellular matrix graft to serve as an "off the shelf" scaffold on which urothelium regenerates, (2) attempts to create a simpler, more durable bowel continence mechanism, and (3) a novel experimental technique for renal preservation based on considering the urine-producing and urine-directing roles of the upper tract as surgically separable entities. These research endeavors serve to illustrate how developments at the molecular and basic science levels promise to lead to further reconstructive surgical approaches when translating new developments into patient benefits during the year 2000 and beyond. by Société Internationale de Chirurgie, 2000 World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1163-1166 0364-2313 24:10<1163 2000 24 268 https://doi.org/10.1007/s002680010195 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010195 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Gardiner Robert A. Department of Surgery, University of Queensland, Royal Brisbane Hospital, Herston 4029, Australia, AU aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1163-1166 0364-2313 24:10<1163 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer