caa a22 4500 475802764 CHVBK 20180406123742.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s002680010252 doi (NATIONALLICENCE)springer-10.1007/s002680010252 Long-term Prognosis for Colon Cancer Related to Consistent Radical Surgery: Multivariate Analysis of Clinical, Surgical, and Pathologic Variables [Elektronische Daten] [Michael Jagoditsch, Peter H. Lisborg, Gerhard R. Jatzko, Viktor Wette, Gerhard Kropfitsch, Helmut Denk, Martin Klimpfinger, Haro M. Stettner] Abstract.: Despite the improvement in its prognosis in most Western countries, death from colon cancer is still a major problem. In a prospectively planned observation study, a large patient collective from a single institution in Austria was analyzed in terms of the surgical approach and factors influencing survival. A total of 696 patients with colonic carcinomas were admitted to our surgical department between January 1, 1984 and December 31, 1997. Radical surgery for localized tumors was consistently performed, including wide resection margins and complete removal of the regional lymph drainage zones. Clinical, histopathologic, and therapy-related factors were examined for their influence on long-term survival by means of univariate and multivariate analysis. The overall tumor resection rate was 99.3% (691/696); complete tumor removal (R0) was possible for 84.8% (590/696) of all patients. The overall postoperative hospital mortality rate was 3.2% (22/696), and it was 1.3% (7/556) for potentially curative resections. Five- and ten-year tumor-specific survival rates for stage I to III R0 resections were 83.8% and 78.8%, respectively. Adjuvant chemotherapy reduced tumor recurrence for stage III patients by 52.4%. The depth of tumor infiltration, lymph node status, and adjuvant chemotherapy were found to have an independent influence on survival as identified by the Cox models. In conclusion, a consistent radical surgical approach for potentially curative resected colonic cancer patients had survival rates that surpassed those of most published series without sacrificing low complication rates. In addition, adjuvant chemotherapy for stage III substantially improved survival. by Société Internationale de Chirurgie, 2000 Jagoditsch Michael Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut Lisborg Peter H. Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut Jatzko Gerhard R. Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut Wette Viktor Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut Kropfitsch Gerhard Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut Denk Helmut Department of Pathological Anatomy, University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria, AT aut Klimpfinger Martin Department of Pathological Anatomy, University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria, AT aut Stettner Haro M. Department of Mathematics and Applied Statistics, University of Klagenfurt, Universitätsstrasse, A-9020 Klagenfurt, Austria, AT aut World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1264-1270 0364-2313 24:10<1264 2000 24 268 https://doi.org/10.1007/s002680010252 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010252 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jagoditsch Michael Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut NATIONALLICENCE 700 1- Lisborg Peter H. Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut NATIONALLICENCE 700 1- Jatzko Gerhard R. Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut NATIONALLICENCE 700 1- Wette Viktor Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut NATIONALLICENCE 700 1- Kropfitsch Gerhard Department of Surgery, Hospital of the Barmherzige Brueder St. Veit/Glan Teaching Hospital, Faculty of Medicine, University of Vienna, Spitalgasse 26, A-9300 St. Veit/Glan, Austria, AT aut NATIONALLICENCE 700 1- Denk Helmut Department of Pathological Anatomy, University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria, AT aut NATIONALLICENCE 700 1- Klimpfinger Martin Department of Pathological Anatomy, University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria, AT aut NATIONALLICENCE 700 1- Stettner Haro M. Department of Mathematics and Applied Statistics, University of Klagenfurt, Universitätsstrasse, A-9020 Klagenfurt, Austria, AT aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/10(2000-10-01), 1264-1270 0364-2313 24:10<1264 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer