caa a22 4500 475802861 CHVBK 20180406123742.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s002689910072 doi (NATIONALLICENCE)springer-10.1007/s002689910072 Significance of Plasma Thymosin α1 Measurements in Gastric Cancer Patients [Elektronische Daten] [Masami Mitani, Yoshiyuki Kuwabara, Hiroyuki Kawamura, Atsushi Sato, Kouji Hattori, Yoshitaka Fujii] Abstract.: Thymosin α1 is a cleavage product of prothymosin α. Expression of prothymosin α increases during cell proliferation. Thymosin α1, measurable in plasma, may be an indicator of cell proliferation especially if a cancer is present. In this report we investigated the relation between the clinical behavior of gastric cancer and the plasma thymosin α1 level. Plasma thymosin α1 was measured in 52 gastric cancer patients using a newly developed radioimmunoassay. Twenty-one tumors and lymph nodes were examined for thymosin α1 using immunohistochemistry. The plasma thymosin α1 level was higher in gastric cancer patients than in normal volunteers; and it was higher in patients with lymph node involvement than in those with negative nodes. Immunohistochemical study of thymosin α1 showed positivity in 52% of gastric cancers and 100% of lymph node metastasis. We concluded that a high level of plasma thymosin α1 suggests aggressive behavior of a gastric cancer, such as lymph node involvement. Société Internationale de Chirurgie, 2000 Mitani Masami Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut Kuwabara Yoshiyuki Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut Kawamura Hiroyuki Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut Sato Atsushi Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut Hattori Kouji Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut Fujii Yoshitaka Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut World Journal of Surgery Springer-Verlag 24/4(2000-04-01), 455-458 0364-2313 24:4<455 2000 24 268 https://doi.org/10.1007/s002689910072 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910072 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mitani Masami Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut NATIONALLICENCE 700 1- Kuwabara Yoshiyuki Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut NATIONALLICENCE 700 1- Kawamura Hiroyuki Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut NATIONALLICENCE 700 1- Sato Atsushi Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut NATIONALLICENCE 700 1- Hattori Kouji Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut NATIONALLICENCE 700 1- Fujii Yoshitaka Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho Mizuho-ku, Nagoya 467, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/4(2000-04-01), 455-458 0364-2313 24:4<455 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer