caa a22 4500 475803035 CHVBK 20180406123742.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s002680010163 doi (NATIONALLICENCE)springer-10.1007/s002680010163 Expanding Role of Fine-needle Aspiration Cytology in Thyroid Diagnosis and Management [Elektronische Daten] [Petra Werga, Göran Wallin, Lamberth Skoog, Bertil Hamberger] In non-iodine-deficient areas, 4% to 7% of the population are reported to have thyroid abnormalities. Prophylactic operations of these nodules in the thyroid are not indicated and not cost-effective, as at least four of five nodules are colloid goiter and only a few are malignant. The need for a reliable preoperative diagnosis is great, and fine-needle aspiration (FNA) is now considered the first choice during workup for thyroid nodules. The steps in the FNA procedure are clinical examination and localization of the target lesion, aspiration, preparation of smears, and collecting material for ancillary microscopy techniques. All these steps must be exercised to allow optimal use of FNA. It can also be combined with various other methods, such as immunohistochemistry of thyroglobulin and calcitonin, analysis of nuclear DNA, DNA preparation for molecular biology analyses, and magnetic resonance spectra. The accuracy of the clinical routine in our unit was evaluated by studying the 5-year outcomes of almost 4000 FNAs of the thyroid. The results were good, with only a few false-negative and false-positive results; but the problem of differentiating follicular adenoma from follicular carcinoma remains a significant problem. It is now well established that FNA biopsy and cytology is the best modality available for the workup of thyroid nodules and is widely utilized in endocrine surgical centers worldwide. Société Internationale de Chirurgie, 2000 Werga Petra Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut Wallin Göran Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut Skoog Lamberth Department of Pathology, Division of Cytology, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut Hamberger Bertil Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut World Journal of Surgery Springer-Verlag 24/8(2000-08-01), 907-912 0364-2313 24:8<907 2000 24 268 https://doi.org/10.1007/s002680010163 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010163 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Werga Petra Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Wallin Göran Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Skoog Lamberth Department of Pathology, Division of Cytology, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 700 1- Hamberger Bertil Department of Surgery, Karolinska Hospital, 171 76 Stockholm, Sweden, SE aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/8(2000-08-01), 907-912 0364-2313 24:8<907 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer