caa a22 4500 475803078 CHVBK 20180406123743.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s002680010170 doi (NATIONALLICENCE)springer-10.1007/s002680010170 Effect of Ischemia/Reperfusion as a Systemic Phenomenon on Anastomotic Healing in the Left Colon [Elektronische Daten] [Mehmet Ayhan Kuzu, Adil Tanık, İIlhami Taner Kale, Ahmet Keşşaf Aşlar, Cüneyt Köksoy, Cem Terzi] Intestinal ischemia/reperfusion provokes a local inflammatory response leading to a systemic inflammatory state. In this study we aimed to assess the effects of intestinal ischemia/reperfusion injury on anastomotic healing in the left colon with an intact vascular supply. A total of 94 Wistar albino rats were divided into three groups: sham-operated control (group I, n= 25), 30 minutes of intestinal ischemia/reperfusion (group II, n= 40), and 7-day allopurinol pretreatment and intestinal ischemia/reperfusion (group III, n= 29). After the reperfusion experiment, a segmental left colon resection and anastomosis were done. On postoperative days 3 and 7 anastomotic bursting pressure, anastomotic and operative complications, and intraabdominal adhesions were assessed. Mortality rates were 1/25, 16/40, and 4/29 for groups I, II, and III, respectively (p= 0.001). There was no difference among the groups for wound and anastomotic healing parameters evaluated by macroscopic criteria. On postoperative day 7 the mean bursting pressures were 220.3 ± 18.5, 162.0 ± 21.0, and 213.9 ± 24.7 for groups I, II, and II, respectively (p= 0.000). Significantly dense adhesions were found in group II (p= 0.000). Allopurinol pretreatment prevented the effects of ischemia/reperfusion on anastomotic healing of the left colon. Intestinal/ischemia reperfusion causes impairment of anastomotic healing of the left colon. In addition to remote organ effects, reperfusion injury may affect anastomotic healing in the viscera with an intact vascular supply. Société Internationale de Chirurgie, 2000 Kuzu Mehmet Ayhan Department of Surgery, Faculty of Medicine, University of Ankara, Sihhiye, 06100 Ankara, Turkey, TR aut Tanık Adil Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut Kale İIlhami Taner Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut Aşlar Ahmet Keşşaf Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut Köksoy Cüneyt Department of Surgery, Faculty of Medicine, University of Ankara, Sihhiye, 06100 Ankara, Turkey, TR aut Terzi Cem Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut World Journal of Surgery Springer-Verlag 24/8(2000-08-01), 990-994 0364-2313 24:8<990 2000 24 268 https://doi.org/10.1007/s002680010170 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010170 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuzu Mehmet Ayhan Department of Surgery, Faculty of Medicine, University of Ankara, Sihhiye, 06100 Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Tanık Adil Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Kale İIlhami Taner Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Aşlar Ahmet Keşşaf Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Köksoy Cüneyt Department of Surgery, Faculty of Medicine, University of Ankara, Sihhiye, 06100 Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Terzi Cem Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, Turkey, TR aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/8(2000-08-01), 990-994 0364-2313 24:8<990 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer