caa a22 4500 475803094 CHVBK 20180406123743.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s002680010165 doi (NATIONALLICENCE)springer-10.1007/s002680010165 Differentiated Thyroid Cancer: "Complete” Rational Approach [Elektronische Daten] [Electron Kebebew, Orlo H. Clark] Controversy continues regarding the optimal management of patients with differentiated thyroid cancer because no prospective randomized studies evaluating the merits of (1) extent of thyroidectomy, (2) postoperative radioactive iodine ablation, or (3) thyroid-stimulating hormone (TSH) suppressive therapy exist. Patients with low risk differentiated thyroid cancer enjoy a relatively good prognosis with a mortality rate of about 2% to 5% and a recurrence rate of about 20%. Despite the excellent prognosis in patients considered to be at low risk, total or near-total thyroidectomy in patients with differentiated thyroid cancer has the advantages that: (1) postoperative radioactive iodine can be used to detect and treat residual normal thyroid tissue and local or distant metastases; (2) follow-up serum thyroglobulin levels are a more sensitive marker of persistent or recurrent disease when all thyroid tissue has been removed; and (3) total or near-total thyroidectomy with postoperative 131I ablation and TSH suppressive therapy is associated with better survival and lower recurrence rates. Patients with occult papillary thyroid cancer and minimally invasive follicular thyroid cancer can be treated by thyroid lobectomy because they have a near-normal life expectancy. Virtually all other patients with differentiated thyroid cancer appear to benefit from more extensive initial treatment. Société Internationale de Chirurgie, 2000 Kebebew Electron Department of Surgery, School of Medicine, University of California, San Francisco, 513 Parnassus Street, San Francisco, California 94143-0470, USA, US aut Clark Orlo H. Department of Surgery, University of California, San Francisco/Mt. Zion Medical Center, 1600 Divisadero Street, San Francisco, California 94143-7921, USA, US aut World Journal of Surgery Springer-Verlag 24/8(2000-08-01), 942-951 0364-2313 24:8<942 2000 24 268 https://doi.org/10.1007/s002680010165 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010165 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kebebew Electron Department of Surgery, School of Medicine, University of California, San Francisco, 513 Parnassus Street, San Francisco, California 94143-0470, USA, US aut NATIONALLICENCE 700 1- Clark Orlo H. Department of Surgery, University of California, San Francisco/Mt. Zion Medical Center, 1600 Divisadero Street, San Francisco, California 94143-7921, USA, US aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/8(2000-08-01), 942-951 0364-2313 24:8<942 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer