caa a22 4500 475803221 CHVBK 20180406123743.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002689910098 doi (NATIONALLICENCE)springer-10.1007/s002689910098 Protein Expression of bax, bcl-2, and p53 in Patients with Non-Hodgkin's Gastric Lymphoma: Prognostic Significance [Elektronische Daten] [George K. Charalambous, Ilias P. Gomatos, Manoussos M. Konstadoulakis, Evangelos G. Messaris, Andreas J. Manouras, Anastasia E. Apostolou, Emmanuel A. Leandros, Maria K. Karayannis, George A. Androulakis] Abstract.: The biologic significance of bcl-2, bax, and p53 gene expression in patients with non-Hodgkin's gastric lymphoma is unknown. We examined the prognostic value of these genes in 36 patients with gastric lymphoma treated in our clinic between 1990 and 1995. Paraffin-embedded specimens from 36 patients who underwent primary resection of the stomach for gastric lymphoma were analyzed immunohistochemically for p53, bax, and bcl-2 gene expression. Expression of bax was seen in 24 of 36 patients (66.7%), p53 expression was found in 8 of 36 tumors (22.2%), and bcl-2 cytoplasmic staining was detected in 6 of 36 patients (16.7%). We performed a univariate analysis to examine the possible correlation between the expression of these genes and the survival of our patients. Expression of bax protein proved to be a statistically significant prognostic factor (p= 0.049). Protein expression of p53 and bcl-2 did not statistically correlate with survival. In the bcl-2-negative (−) patient group (30 patients), those who were bax-positive had a statistically significant better survival than those who were bax-negative (63.3% vs. 36.7%, p= 0.03). There was also a statistically significant correlation between p53 expression and the grade of the tumor (p= 0.0014). P53 protein expression increased along with the grade. Expression of bax is a significant prognostic factor in patients with gastric lymphoma. Its prognostic value increases significantly when studied in bcl-2-negative patients; but expression of bax failed to be an independent prognostic factor. Expression of bcl-2 and p53 has no prognostic significance. Expression of p53 seems to represent a marker for loss of differentiation. 2000 by the Société Internationale de Chir, 2000 Charalambous George K. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Gomatos Ilias P. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Konstadoulakis Manoussos M. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Messaris Evangelos G. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Manouras Andreas J. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Apostolou Anastasia E. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Leandros Emmanuel A. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Karayannis Maria K. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut Androulakis George A. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 608-614 0364-2313 24:5<608 2000 24 268 https://doi.org/10.1007/s002689910098 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Charalambous George K. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Gomatos Ilias P. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Konstadoulakis Manoussos M. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Messaris Evangelos G. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Manouras Andreas J. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Apostolou Anastasia E. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Leandros Emmanuel A. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Karayannis Maria K. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 700 1- Androulakis George A. First Department of Propaedeutic Surgery, Laboratory of Surgical Research, Hippocration Hospital of Athens, Athens University, 114 Queen's Sofia Avenue, 115 27, Athens, Greece, GR aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 608-614 0364-2313 24:5<608 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer