caa a22 4500 475803329 CHVBK 20180406123743.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002689910081 doi (NATIONALLICENCE)springer-10.1007/s002689910081 Does Hyperthermia Induce Peritoneal Damage in Continuous Hyperthermic Peritoneal Perfusion? [Elektronische Daten] [Akemi Shido, Shigeo Ohmura, Ken Yamamoto, Tsutomu Kobayashi, Takashi Fujimura, Yutaka Yonemura] Abstract.: To investigate the mechanisms of the peritoneal damage induced by continuous hyperthermic peritoneal perfusion (CHPP), protein and fluid loss during and after CHPP and continuous normothermic peritoneal perfusion (CNPP) was studied. Sixteen patients with advanced gastric cancer underwent peritoneal perfusion therapy with saline solution containing 150 to 300 mg cisplatin and 30 to 60 mg mitomycin C for 60 minutes. The temperature in Douglas' pouch was maintained at 42.0°C in the CHPP group (n= 9) and 37.0°C in the CNPP group (n= 7) during perfusion. No statistical differences were found in patients' characteristics between the groups except the maximum temperature in Douglas' pouch during perfusion (41.6°± 0.4°C and 37.6°± 0.4°C in CHPP and CNPP groups, respectively, p < 0.05). The amount of protein lost into the perfusate was 0.35 ± 0.22 g/kg body weight in the CHPP group and 0.37 ± 0.19 g/kg in the CNPP group, showing no significant difference. On the day of surgery, there was no significant difference in the amount of protein and fluid lost through the abdominal drains between the CHPP group (27.9 ± 24.6 mg/kg/hr and 0.94 ± 0.63 ml/kg/hr, respectively) and the CNPP group (25.9 ± 8.6 mg/kg/hr and 1.03 ± 0.31 ml/kg/hr, respectively). We could not find any significant differences in postoperative protein and fluid loss between the groups on the following 3 days either. We conclude that the peritoneal damage by CHPP is not caused by the hyperthermia but by the peritoneal perfusion with saline solution containing anticancer drugs. 2000 by the Société Internationale de Chir, 2000 Shido Akemi Department of Anesthesiology, Tatsunokuchi Houju Memorial Hospital, 11-71 Midorigaoka, Tatsunokuchi-machi, Nomi-gun 923-1226, Japan, JP aut Ohmura Shigeo Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut Yamamoto Ken Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut Kobayashi Tsutomu Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut Fujimura Takashi Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut Yonemura Yutaka Department of Surgery II, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 507-511 0364-2313 24:5<507 2000 24 268 https://doi.org/10.1007/s002689910081 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910081 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shido Akemi Department of Anesthesiology, Tatsunokuchi Houju Memorial Hospital, 11-71 Midorigaoka, Tatsunokuchi-machi, Nomi-gun 923-1226, Japan, JP aut NATIONALLICENCE 700 1- Ohmura Shigeo Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut NATIONALLICENCE 700 1- Yamamoto Ken Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut NATIONALLICENCE 700 1- Kobayashi Tsutomu Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut NATIONALLICENCE 700 1- Fujimura Takashi Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut NATIONALLICENCE 700 1- Yonemura Yutaka Department of Surgery II, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 507-511 0364-2313 24:5<507 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer