caa a22 4500 475803353 CHVBK 20180406123743.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002689910086 doi (NATIONALLICENCE)springer-10.1007/s002689910086 Complicated Enterocutaneous Fistulas: Failure of Octreotide to Improve Healing [Elektronische Daten] [Carlos Alvarez, David W. McFadden, Howard A. Reber] Abstract.: Octreotide has been promoted as a potential aid during closure of enterocutaneous fistulas (ECFs) on the basis of clinical and experimental evidence that it can reduce gastrointestinal secretions. We retrospectively reviewed the records of patients admitted with ECF to our tertiary referral center to ascertain whether use of octreotide affected fistula duration, length of hospitalization, closure rate, and morbidity. Of 60 patients diagnosed and treated for ECF over a 4-year period, 13 underwent a therapeutic trial with octreotide. Thirteen patients from the group who did not receive octreotide were matched by cause, location, and output of the fistula, age, and primary diagnosis to the treatment group. Octreotide was administered in therapeutic dosage for a mean course of 57 ± 29 days, resulting in a substantial acute decrease (84.7 ± 4.8%) in fistula output. Prolonged therapy nevertheless failed to affect the outcome parameters studied, particularly fistula duration, spontaneous closure rate, and length of hospitalization. There was a significantly higher incidence of septic and thrombotic complications associated with octreotide use. In this patient population with complicated ECFs, use of octreotide showed no benefit and was associated with increased morbidity. 2000 by the Société Internationale de Chir, 2000 Alvarez Carlos Surgical Service (112), Baltimore Veterans Administration Medical Center, 10 N. Greene Street, Baltimore, Maryland 21201, USA, US aut McFadden David W. Division of General Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA, US aut Reber Howard A. Division of General Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA, US aut World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 533-538 0364-2313 24:5<533 2000 24 268 https://doi.org/10.1007/s002689910086 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910086 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alvarez Carlos Surgical Service (112), Baltimore Veterans Administration Medical Center, 10 N. Greene Street, Baltimore, Maryland 21201, USA, US aut NATIONALLICENCE 700 1- McFadden David W. Division of General Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA, US aut NATIONALLICENCE 700 1- Reber Howard A. Division of General Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA, US aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 533-538 0364-2313 24:5<533 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer