caa a22 4500 47580340X CHVBK 20180406123744.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002689910099 doi (NATIONALLICENCE)springer-10.1007/s002689910099 Long-term Survival of Transmural Advanced Gastric Carcinoma following Curative Resection: Multivariate Analysis of Prognostic Factors [Elektronische Daten] [Dipok Kumar Dhar, Hirofumi Kubota, Mitsuo Tachibana, Tsukasa Kotoh, Hideki Tabara, Reiko Watanabe, Hitoshi Kohno, Naofumi Nagasue] Abstract.: Patients with transmural (T2N0-T3N2) advanced gastric carcinoma comprise the largest group with uncertain outcome. These patients must be stratified according to the prognostic variables so the high risk group can be precisely identified. A total of 152 patients with transmural advanced gastric carcinomas were uniformly treated with a curative intent between 1979 and 1989 with at least a 7-year follow-up. Results and prognostic factors of long-term survival were analyzed by univariate and multivariate analyses. Seventy-five (49%) patients with advanced gastric carcinoma survived more than 7 years, which indicates the curative nature of surgery for gastric carcinoma. Seventeen variables were evaluated by univariate analysis. In the multivariate analysis, patient's age [> 70 years, relative risk (RR) 2.4)], intraoperative blood loss (> 500 ml, RR 1.7), blood vessel invasion (RR 2.3), ratio of invaded dissected lymph nodes (> 0.2, RR 3.0), and tumors penetrating the serosa (RR 3.9) were the independent prognostic variables. The results of this study indicate that extensive lymphadenectomy and minimal intraoperative blood loss might be helpful for improving patient survival following a curative resection. Patients with vessel invasion, serosal involvement, and those > 70 years of age should be considered at high risk and require appropriate adjuvant therapy to prolong survival. 2000 by the Société Internationale de Chir, 2000 Dhar Dipok Kumar Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Kubota Hirofumi Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Tachibana Mitsuo Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Kotoh Tsukasa Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Tabara Hideki Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Watanabe Reiko Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Kohno Hitoshi Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut Nagasue Naofumi Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 588-594 0364-2313 24:5<588 2000 24 268 https://doi.org/10.1007/s002689910099 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910099 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dhar Dipok Kumar Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Kubota Hirofumi Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Tachibana Mitsuo Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Kotoh Tsukasa Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Tabara Hideki Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Watanabe Reiko Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Kohno Hitoshi Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 700 1- Nagasue Naofumi Second Department of Surgery, Shimane Medical University, Enyacho 89-1, Izumo 693, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 588-594 0364-2313 24:5<588 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer