caa a22 4500 475803418 CHVBK 20180406123744.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002689910096 doi (NATIONALLICENCE)springer-10.1007/s002689910096 Measuring the Tumor Volume of Gastric Carcinoma by Computer Image Analysis: Clinical Significance [Elektronische Daten] [Shiro Kikuchi, Yoshiki Hiki, Yuzuru Sakakibara, Akira Kakita, Sadahito Kuwao] Abstract.: The tumor diameter of gastric carcinoma, measured by gross or histologic examination, is a rough indicator of actual tumor size. Therefore we investigated the utility of three-dimensional reconstruction of tumors in gastric carcinoma. Altogether 105 primary gastric carcinoma lesions, consisting of 16 advanced and 89 early carcinomas, were analyzed. A total of 942 lesion tissue sections, comprising 2 to 37 sections per lesion (mean 9 sections), were examined histologically. Surface rendering using a computer graphics analysis program was then performed from serial sections to create a three-dimensional reconstruction of tumor morphology from which to measure tumor volume. For the 105 lesions the tumor diameter ranged between 4 and 106 mm (average ± SE: 32.4 ± 2.0 mm), and tumor volume ranged between 4 and 5853 mm3 (average ± SE: 773.0 ± 104.6 mm3). A significant correlation was found between tumor diameter and the log of the tumor volume (r= 0.733, p < 0.0001). Although the logs of tumor volume for advanced carcinomas were all > 2.5, in 11 of these 16 patients (66%) the tumor diameter was < 4 cm, and in one patient < 2 cm. In addition, tumor diameter did not differ significantly between the 16 advanced and the 89 early gastric carcinomas (p= 0.114), whereas the log of the tumor volume did (p < 0.0001). In conclusion, conventional measurements of tumor diameter as a rough indicator of tumor size can predict the actual tumor size of a gastric carcinoma. Three-dimensional reconstruction using computer graphics provides a better estimation of true tumor size and extent of progression than tumor diameter. 2000 by the Société Internationale de Chir, 2000 Kikuchi Shiro Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Hiki Yoshiki Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Sakakibara Yuzuru Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Kakita Akira Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Kuwao Sadahito Department of Pathology, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 603-607 0364-2313 24:5<603 2000 24 268 https://doi.org/10.1007/s002689910096 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910096 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kikuchi Shiro Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Hiki Yoshiki Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Sakakibara Yuzuru Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Kakita Akira Department of Surgery, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Kuwao Sadahito Department of Pathology, School of Medicine, Kitasato University, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 603-607 0364-2313 24:5<603 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer