caa a22 4500 475803426 CHVBK 20180406123744.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002689910090 doi (NATIONALLICENCE)springer-10.1007/s002689910090 Prospective Case-controlled Trial of Adjuvant Chemotherapy after Resection of Hepatocellular Carcinoma [Elektronische Daten] [Yi-Hsiang Huang, Jaw-Ching Wu, Wing-Yiu Lui, Gar-Yang Chau, Shih-Haw Tsay, Jen-Huey Chiang, Kuang-Liang King, Teh-Ia Huo, Full-Young Chang, Shou-Dong Lee] Abstract.: Recurrence of hepatocellular carcinoma (HCC) after curative hepatic resection is frequent and is an important factor adversely influencing long-term survival. The role of postoperative chemotherapy in the reduction of tumor recurrence rate is still controversial. During the period of 1992-1995 a series of 49 patients who underwent curative resection of HCC and had at least one risk factor of tumor recurrence were followed in this prospective study. Patients were allocated to adjuvant chemotherapy and control groups. Twenty-four patients received a combination of low dose intravenous epirubicin (20 mg/m2) and mitomycin (5 mg) monthly for seven courses starting 5 to 6 weeks after surgery. Twenty-five patients had no adjuvant treatment. The disease-free and overall survivals were compared for the two groups. A total of 154 courses of chemotherapy were given to the 24 patients. The chemotherapy-related side effects were mild and tolerable with no mortality. At a median follow-up of 39 months (range 9-71 months), 9 patients in the adjuvant chemotherapy group and 16 patients in the control group developed tumor recurrence. The respective 1-, 2-, 3-, and 5-year disease-free survival rates were 75%, 67%, 63%, and 63% for patients in the adjuvant chemotherapy group and 68%, 42%, 37%, and 32% for patients in the control group (p= 0.0575). The 1-, 2-, 3-, and 5-year overall survival rates were 100%, 96%, 77%, and 72% in the adjuvant chemotherapy group and 92%, 67%, 63%, and 51% in the control group (p= 0.0746). In conclusion, postoperative adjuvant chemotherapy using the present regimen has a tendency to reduce tumor recurrence rate and may improve long-term survival for high risk patients. 2000 by the Société Internationale de Chir, 2000 Huang Yi-Hsiang Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Wu Jaw-Ching Department of Medicine, Division of Gastroenterology, Institute of Clinical Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Lui Wing-Yiu Department of Surgery, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Chau Gar-Yang Department of Surgery, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Tsay Shih-Haw Department of Pathology, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Chiang Jen-Huey Department of Radiology, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut King Kuang-Liang Department of Surgery, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Huo Teh-Ia Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Chang Full-Young Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut Lee Shou-Dong Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 551-555 0364-2313 24:5<551 2000 24 268 https://doi.org/10.1007/s002689910090 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689910090 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Yi-Hsiang Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Wu Jaw-Ching Department of Medicine, Division of Gastroenterology, Institute of Clinical Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Lui Wing-Yiu Department of Surgery, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Chau Gar-Yang Department of Surgery, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Tsay Shih-Haw Department of Pathology, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Chiang Jen-Huey Department of Radiology, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- King Kuang-Liang Department of Surgery, Veterans General Hospital-Taipei, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Huo Teh-Ia Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Chang Full-Young Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 700 1- Lee Shou-Dong Department of Medicine, Division of Gastroenterology, School of Medicine, Veterans General Hospital-Taipei, National Yang-Ming University, 201 Shih-Pai Road, Sec. 2, Taipei 112, Taiwan, Republic of China, CN aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/5(2000-05-01), 551-555 0364-2313 24:5<551 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer