caa a22 4500 475803604 CHVBK 20180406123744.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s002680010233 doi (NATIONALLICENCE)springer-10.1007/s002680010233 Familial Papillary Thyroid Carcinoma: Genetics, Criteria for Diagnosis, Clinical Features, and Surgical Treatment [Elektronische Daten] [Thomas J. Musholt, Petra B. Musholt, Thorsten Petrich, Gundula Oetting, Wolfram H. Knapp, Juergen Klempnauer] Hereditable predisposition to papillary thyroid carcinoma (PTC) and multinodular goiter (MNG) without evidence of an association with other malignancies as a distinct entity was recognized only recently. A meta-review of the literature on familial PTC (FPTC) was undertaken, and characteristics of families with frequent occurrence of PTC or MNG (or both) were summarized. A database on thyroid cancer patients maintained in our institution was searched for potential FPTC families. Clinical examinations were performed in 6 of 12 Hannover kindreds identified, and blood samples of all family members were collected for genetic analyses. Clinical presentations and histopathologic features of the FPTC cases were compiled. Based on the FPTC meta-review and own experience, predictive criteria to identify families at risk were developed: Exclusion criteria were previous radiation exposure and coincidence with neoplasia syndromes. Primary criteria for susceptibility to FPTC are (1) PTC in two or more first-degree relatives and (2) MNG in at least three first- or second-degree relatives of a PTC patient. Secondary criteria are diagnosis in a patient younger than 33 years, multifocal or bilateral PTC, organ-exceeding tumor growth (T4), metastasis (N1, M1), and familial accumulation of adolescent-onset thyroid disease. A hereditary predisposition to PTC is considered if both primary criteria or one primary criterion plus three secondary criteria are present. Family history-taking is recommended for all PTC patients to identify FPTC kindreds at risk. Blood relatives of FPTC index patients who harbor MNG should undergo thorough and regular clinical screening. Suspicious lesions should prompt early surgical intervention. Société Internationale de Chirurgie, 2000 Musholt Thomas J. Department of Visceral and Transplantation Surgery, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut Musholt Petra B. Department of Visceral and Transplantation Surgery, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut Petrich Thorsten Department of Nuclear Medicine and Special Biophysics, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut Oetting Gundula Department of Nuclear Medicine and Special Biophysics, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut Knapp Wolfram H. Department of Nuclear Medicine and Special Biophysics, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut Klempnauer Juergen Department of Visceral and Transplantation Surgery, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1409-1417 0364-2313 24:11<1409 2000 24 268 https://doi.org/10.1007/s002680010233 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010233 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Musholt Thomas J. Department of Visceral and Transplantation Surgery, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Musholt Petra B. Department of Visceral and Transplantation Surgery, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Petrich Thorsten Department of Nuclear Medicine and Special Biophysics, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Oetting Gundula Department of Nuclear Medicine and Special Biophysics, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Knapp Wolfram H. Department of Nuclear Medicine and Special Biophysics, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Klempnauer Juergen Department of Visceral and Transplantation Surgery, Hannover University Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany, DE aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1409-1417 0364-2313 24:11<1409 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer