caa a22 4500 475803728 CHVBK 20180406123744.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s002680010234 doi (NATIONALLICENCE)springer-10.1007/s002680010234 Management of Nonfunctioning Islet Cell Carcinomas [Elektronische Daten] [Detlef K. Bartsch, Thomas Schilling, Annette Ramaswamy, Berthold Gerdes, Ilhan Celik, Hans-Joachim Wagner, Babette Simon, Matthias Rothmund] Tumors arising from the pancreatic islet cells are rare and represent a heterogeneous group of benign or malignant lesions. Most tumors present with well characterized syndromes, whereas others appear to be nonfunctioning. The clinical features of 11 men and 7 women with nonfunctioning islet cell carcinomas operated on between 1983 and 1998 were reviewed. The median patient age was 53.5 years (range 26-74 years). The most frequent presenting symptoms were abdominal pain (13 patients), weight loss (7 patients), and obstructive jaundice (4 patients). Gut hormone profiles were normal in all patients. Abdominal sonography and computed tomography localized the tumor in 17 patients, and correct prediction of an endocrine tumor was achieved in 12 patients. Six of seven patients showed a hypervascular tumor upon angiograpy, and seven of eight patients preoperatively had positive somatostatin receptor scintigraphy. At operation, regional or distant metastases were present in 15 (83%) and 6 (33%) patients, respectively. Eleven patients underwent potentially curative resections, and the remaining seven patients were managed palliatively by resection (four patients) or bypass procedures (three patients). Three patients had up to three more resection for metastases. Eight patients received postoperative octreotide, interferon α therapy, or both. The overall cumulative 5- and 10-year survival rates were 65.4% and 49.1%, respectively. Of the 11 patients who underwent curative resection, 10 were alive after a median follow-up of 63 months (range 7-180 months), but only 5 are free from disease. Although surgical cure is rare in nonfunctioning islet cell carcinomas, significant long-term palliation can be achieved in a large proportion of patients with an aggressive surgical approach and, when indicated, additional medical therapy. Société Internationale de Chirurgie, 2000 Bartsch Detlef K. Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Schilling Thomas Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Ramaswamy Annette Department of Pathology, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Gerdes Berthold Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Celik Ilhan Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Wagner Hans-Joachim Department of Radiology, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Simon Babette Department of Internal Medicine, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut Rothmund Matthias Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1418-1424 0364-2313 24:11<1418 2000 24 268 https://doi.org/10.1007/s002680010234 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010234 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bartsch Detlef K. Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Schilling Thomas Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Ramaswamy Annette Department of Pathology, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Gerdes Berthold Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Celik Ilhan Institute of Theoretical Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Wagner Hans-Joachim Department of Radiology, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Simon Babette Department of Internal Medicine, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 700 1- Rothmund Matthias Department of Surgery, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany, DE aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1418-1424 0364-2313 24:11<1418 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer