caa a22 4500 475803779 CHVBK 20180406123745.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s002680010236 doi (NATIONALLICENCE)springer-10.1007/s002680010236 Gastrointestinal Carcinoid Tumors: Long-term Prognosis for Surgically Treated Patients [Elektronische Daten] [Jon Arne Söreide, Jon A. van Heerden, Geoffrey B. Thompson, Cathy Schleck, Duane M. Ilstrup, Marilyn Churchward] To evaluate long-term survival of patients with gastrointestinal carcinoid tumors and to assess factors that may influence prognosis, 154 patients (49% females, 51% males), median age 62 years (range 12-84 years) treated at our institution during 1972-1982 have been followed long term. Tumor location included the foregut (7%), midgut (62%), and hindgut (30%). Ninety-five percent of the patients underwent surgical or endoscopic excision of the primary tumor, with overall operative mortality and postoperative morbidity rates of 2.6% and 11%, respectively. At follow-up, 60 patients (39%) were alive (median follow-up 18 years; range 1-26 years). The main causes of death included carcinoid tumor burden (32%), unrelated causes (45%), other malignancy (19%), and unknown causes (4%). Observed overall 5- and 10-year survivals were 69% and 53%, respectively. Survival was not related to gender or symptoms at presentation. However, age, embryologic origin, tumor size, depth of invasion, nodal status, and stage of disease proved to be of statistical significance (log-rank). In a multivariate Cox' model, only older age (> 62 years) [P =0.001, odds ratio (OR) = 3.4) and embryologic origin (midgut versus foregut) (P = 0.045, OR = 0.45) provided independent prognostic power when death from any cause was taken as the end-point. This study confirms that patient's age and the site of the primary tumor have prognostic significance. Carcinoid tumors are neuroendocrine tumors with a relatively good prognosis, and long-term survival is possible despite advanced stages of disease. Société Internationale de Chirurgie, 2000 Söreide Jon Arne Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut van Heerden Jon A. Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut Thompson Geoffrey B. Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut Schleck Cathy Section of Biostatistics, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut Ilstrup Duane M. Section of Biostatistics, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut Churchward Marilyn Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1431-1436 0364-2313 24:11<1431 2000 24 268 https://doi.org/10.1007/s002680010236 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010236 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Söreide Jon Arne Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut NATIONALLICENCE 700 1- van Heerden Jon A. Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut NATIONALLICENCE 700 1- Thompson Geoffrey B. Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut NATIONALLICENCE 700 1- Schleck Cathy Section of Biostatistics, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut NATIONALLICENCE 700 1- Ilstrup Duane M. Section of Biostatistics, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut NATIONALLICENCE 700 1- Churchward Marilyn Department of Surgery, Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, 200 First Street, Rochester, Minnesota 55905, USA, US aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1431-1436 0364-2313 24:11<1431 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer